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    CG10116 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39515, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG10116provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036367
    Locus tag
    Dmel_CG10116
    See related
    AllianceGenome:FB:FBgn0036367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10116
    Summary
    Predicted to be involved in lipid catabolic process. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); familial hyperlipidemia (multiple); hypotrichosis 7; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including LIPC (lipase C, hepatic type); LIPG (lipase G, endothelial type); and LIPH (lipase H). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG10116 in Genome Data Viewer
    Location:
    70B1-70B1; 3-40 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13456208..13457238, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13449308..13450338, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene combover Neighboring gene Jumonji domain containing 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene starvin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Split-GAL4 Drivers and Enhancers That Allow Regional Cell Type Manipulations of the Drosophila melanogaster Intestine. Ariyapala IS, et al. Genetics, 2020 Dec. PMID 32988987, Free PMC Article
    2. MicroRNA mediated regulation of the onset of enteroblast differentiation in the Drosophila adult intestine. Mukherjee S, et al. Cell Rep, 2022 Oct 18. PMID 36261011, Free PMC Article
    3. A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis. Mukherjee S, et al. Proc Natl Acad Sci U S A, 2021 May 25. PMID 34016750, Free PMC Article
    4. I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells. Buddika K, et al. Development, 2021 Jan 7. PMID 33246929, Free PMC Article
    5. Association of Wolbachia with Gene Expression in Drosophila Testes. Dou W, et al. Microb Ecol, 2021 Oct. PMID 33555369

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    NOT enables lipase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10116-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13456208..13457238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140395.2 → NP_648652.1  uncharacterized protein Dmel_CG10116 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648652.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UN78, Q9VU78
      Related
      FBpp0075566
      Conserved Domains (1) summary
      cl21494
      Location:24 → 274
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SZV2 Q8SZV2
    Q9VU78 Q9VU78

    Gene LinkOut

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