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    mbf1 multiprotein bridging factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39842, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mbf1provided by FlyBase
    Official Full Name
    multiprotein bridging factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0262732
    Locus tag
    Dmel_CG4143
    See related
    AllianceGenome:FB:FBgn0262732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10148; BcDNA:GM01267; CG4143; Dmel\CG4143; Mbf-1; MBF-1; Mbf1; MBF1; MRE4
    Summary
    Enables mRNA binding activity and transcription coactivator activity. Involved in central nervous system development; open tracheal system development; and positive regulation of macromolecule biosynthetic process. Located in cytosol and nucleus. Is expressed in adult head; central nervous system; imaginal disc; organism; and testis. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mbf1 in Genome Data Viewer
    Location:
    73A9-73A9; 3-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16574436..16576871)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16567536..16569971)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multiple inositol polyphosphate phosphatase 1 Neighboring gene Ubiquinol-cytochrome c reductase 6.4 kDa subunit-like Neighboring gene nuclear RNA export factor 2 Neighboring gene pseudo Neighboring gene survival motor neuron

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila. Jindra M, et al. EMBO J, 2004 Sep 1. PMID 15306851, Free PMC Article
    2. Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila. Roignant JY, et al. RNA, 2003 Mar. PMID 12592004, Free PMC Article
    3. Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Liu QX, et al. Development, 2003 Feb. PMID 12506002
    4. Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman. Nishioka K, et al. Development, 2018 Mar 9. PMID 29523653, Free PMC Article
    5. Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster. Matsuoka S, et al. Genetics, 2017 Jun. PMID 28396508, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Mbf1 associates with E(z) mRNA and protects it from degradation by the exoribonuclease Pacman (Pcm), thereby ensuring Polycomb silencing.
      Title: Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman.
    2. These data demonstrate a crucial role of MBF1 in the development of tracheae and central nervous system
      Title: Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems.
    3. by preserving the redox-sensitive AP-1 activity, MBF1 provides an advantage during oxidative stress
      Title: Coactivator MBF1 preserves the redox-dependent AP-1 activity during oxidative stress in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in open tracheal system development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in open tracheal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    multiprotein bridging factor 1
    Names
    CG4143-PA
    CG4143-PB
    CG4143-PC
    CG4143-PD
    CG4143-PE
    mRNA-like ncRNA in embryogenesis 4
    mbf1-PA
    mbf1-PB
    mbf1-PC
    mbf1-PD
    mbf1-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16574436..16576871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259867.1 → NP_001246796.1  multiprotein bridging factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246796.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ03
      Conserved Domains (2) summary
      cl26727
      Location:12 → 144
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:3 → 69
      MBF1; Multiprotein bridging factor 1

    2. NM_168673.2 → NP_730178.1  multiprotein bridging factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ03
      Related
      FBpp0075152
      Conserved Domains (2) summary
      cl26727
      Location:12 → 144
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:3 → 69
      MBF1; Multiprotein bridging factor 1

    3. NM_001259866.1 → NP_001246795.1  multiprotein bridging factor 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246795.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ03
      Conserved Domains (2) summary
      cl26727
      Location:12 → 144
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:3 → 69
      MBF1; Multiprotein bridging factor 1

    4. NM_079386.2 → NP_524110.1  multiprotein bridging factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524110.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ03
      Related
      FBpp0075151
      Conserved Domains (2) summary
      cl26727
      Location:12 → 144
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:3 → 69
      MBF1; Multiprotein bridging factor 1

    5. NM_001275023.1 → NP_001261952.1  multiprotein bridging factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261952.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR6
      Conserved Domains (3) summary
      COG1813
      Location:12 → 144
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam01381
      Location:79 → 131
      HTH_3; Helix-turn-helix
      pfam08523
      Location:2 → 70
      MBF1; Multiprotein bridging factor 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PFR6 M9PFR6
    Q8MT00 Q8MT00
    Q9XZ03 Q9XZ03

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