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    St1 Sulfotransferase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    St1provided by FlyBase
    Official Full Name
    Sulfotransferase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0034887
    Locus tag
    Dmel_CG5428
    See related
    AllianceGenome:FB:FBgn0034887
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5428; Dmel\CG5428; dmST1; st1
    Summary
    Enables sulfotransferase activity. Involved in sulfation and xenobiotic metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including embryonic anal pad; embryonic head epidermis; embryonic large intestine; epidermis; and gut section. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive congenital ichthyosis 14; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1B1 (sulfotransferase family 1B member 1); SULT1C3 (sulfotransferase family 1C member 3); and SULT1E1 (sulfotransferase family 1E member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See St1 in Genome Data Viewer
    Location:
    59F6-59F6; 2-104 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23681623..23682952)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19569146..19570475)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45153 Neighboring gene retained Neighboring gene Phosphodiesterase 8 Neighboring gene lethal (2) essential for life Neighboring gene Sulfotransferase 3 Neighboring gene uncharacterized protein Neighboring gene Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transient rapamycin treatment during developmental stage extends lifespan in Mus musculus and Drosophila melanogaster. Aiello G, et al. EMBO Rep, 2022 Sep 5. PMID 35796299, Free PMC Article
    2. Cloning, expression, and characterization of cytosolic sulfotransferase isozymes from Drosophila melanogaster. Hattori K, et al. Biosci Biotechnol Biochem, 2008 Feb. PMID 18256476
    3. Expression analysis of a family of developmentally-regulated cytosolic sulfotransferases (SULTs) in Drosophila. Fahmy K, et al. Hereditas, 2013 Jun. PMID 23865965
    4. [Identification of C(2)M interacting proteins by yeast two-hybrid screening]. Yue SS, et al. Yi Chuan, 2015 Nov. PMID 26582530
    5. siRNA screen identifies QPCT as a druggable target for Huntington's disease. Jimenez-Sanchez M, et al. Nat Chem Biol, 2015 May. PMID 25848931, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfotransferase 1
    Names
    CG5428-PB
    St1-PB
    NP_611815.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23681623..23682952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137971.3 → NP_611815.3  sulfotransferase 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611815.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UND3, Q7K2T0, Q9W1L8
      Conserved Domains (1) summary
      pfam00685
      Location:67 → 322
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W1L8 Q9W1L8

    Gene LinkOut

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