beta4GalNAcTA beta1,4-N-acetylgalactosaminyltransferase A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: beta4GalNAcTAprovided by FlyBase
Official Full Name: beta1,4-N-acetylgalactosaminyltransferase Aprovided by FlyBase
Primary source: FLYBASE:FBgn0027538
Locus tag: Dmel_CG8536
See related: AllianceGenome:FB:FBgn0027538
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.128; b4GalNAcTA; BcDNA:GH13356; beta4Gal-NAcTA; beta4GalNAcT1; beta4GalNacTA; beta4GalTA; CG8536; dbeta4GalTA; Dmel\CG8536; DmGalT
Summary: Enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity and beta-1,4-N-acetylgalactosaminyltransferase activity. Involved in several processes, including N-acetylglucosamine metabolic process; adult locomotory behavior; and glycosphingolipid biosynthetic process. Located in Golgi apparatus. Is expressed in embryonic/larval garland cell and organism. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and congenital disorder of glycosylation type IId. Orthologous to several human genes including B4GALT1 (beta-1,4-galactosyltransferase 1); B4GALT2 (beta-1,4-galactosyltransferase 2); and B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 50E6-50E6; 2-69 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14259030..14261150)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (10146535..10148655)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Larvae mutant for beta4GalNAcTA display distinct nerve and muscle phenotypes.
Title: Functional roles for beta1,4-N-acetlygalactosaminyltransferase-A in Drosophila larval neurons and muscles.
Acts on the terminal N-Acetylglucosamine residue of some glycans for the synthesis of N-acetylgalactosaminyl-1-4-N-acetylglucosamine.
Title: Drosophila beta 1,4-N-acetylgalactosaminyltransferase-A synthesizes the LacdiNAc structures on several glycoproteins and glycosphingolipids.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-1,4-N-acetylgalactosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycosphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: beta1,4-N-acetylgalactosaminyltransferase A

Names: CG8536-PA; beta1,4-N-acetylgalactosaminyltransferase; beta4GalNAcTA-PA

NP_610946.1

EC 2.4.-.-

EC 2.4.1.244

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14259030..14261150

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_137102.4 → NP_610946.1 beta1,4-N-acetylgalactosaminyltransferase A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610946.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KN92

Related

FBpp0086668

Conserved Domains (1) summary

cd00899
Location:181 → 395

b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids