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    CG30281 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG30281provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0050281
    Locus tag
    Dmel_CG30281
    See related
    AllianceGenome:FB:FBgn0050281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AAM68209; CG6676; Dmel\CG30281; FBpp0071674
    Summary
    Predicted to enable G protein-coupled receptor binding activity and chitin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to several human genes including MFAP4 (microfibril associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG30281 in Genome Data Viewer
    Location:
    58B9-58B9; 2-98 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22114997..22116189)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18002502..18003694)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Pleckstrin homology and RUN domain containing M1 Neighboring gene Verprolin 1 Neighboring gene uncharacterized protein Neighboring gene meiotic from via Salaria 332 Neighboring gene Golgi matrix protein 130 kD

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recently evolved genes identified from Drosophila yakuba and D. erecta accessory gland expressed sequence tags. Begun DJ, et al. Genetics, 2006 Mar. PMID 16361246, Free PMC Article
    2. Identification and characterization of the fibrinogen-like domain of fibrinogen-related proteins in the mosquito, Anopheles gambiae, and the fruitfly, Drosophila melanogaster, genomes. Wang X, et al. BMC Genomics, 2005 Sep 8. PMID 16150145, Free PMC Article
    3. Evolution and potential function of fibrinogen-like domains across twelve Drosophila species. Middha S, et al. BMC Genomics, 2008 May 30. PMID 18513432, Free PMC Article
    4. Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Zdobnov EM, et al. Science, 2002 Oct 4. PMID 12364792
    5. Gene Protein Sequence Evolution Can Predict the Rapid Divergence of Ovariole Numbers in the Drosophila melanogaster Subgroup. Whittle CA, et al. Genome Biol Evol, 2024 Jul 3. PMID 38848313, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG30281-PA
    Fibrinogen-related protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22114997..22116189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166512.2 → NP_726164.1  uncharacterized protein Dmel_CG30281 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95SM8
      Related
      FBpp0071674
      Conserved Domains (1) summary
      cd00087
      Location:63 → 274
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95SM8 Q95SM8

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