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    Ser7 Ser7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ser7provided by FlyBase
    Official Full Name
    Ser7provided by FlyBase
    Primary source
    FLYBASE:FBgn0019929
    Locus tag
    Dmel_CG2045
    See related
    AllianceGenome:FB:FBgn0019929
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-SP3; CG2045; cSP3; Dmel\CG2045; SP#2; SP2; SP3
    Summary
    Enables serine hydrolase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ser7 in Genome Data Viewer
    Location:
    9A2-9A2; 1-30 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9865233..9867070)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9759266..9761103)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Carbonic anhydrase-related protein B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction of a putative serine protease transcript in immune challenged Drosophila. Coustau C, et al. Dev Comp Immunol, 1996 Jul-Aug. PMID 8915628
    2. Expression and regulation of Spätzle-processing enzyme in Drosophila. Mulinari S, et al. FEBS Lett, 2006 Oct 2. PMID 16996061
    3. An evolutionarily conserved serine protease network mediates melanization and Toll activation in Drosophila. Shan T, et al. Sci Adv, 2023 Dec 22. PMID 38117884, Free PMC Article
    4. X-linked variation in immune response in Drosophila melanogaster. Hill-Burns EM, et al. Genetics, 2009 Dec. PMID 19822734, Free PMC Article
    5. A kappaB sequence code for pathway-specific innate immune responses. Busse MS, et al. EMBO J, 2007 Aug 22. PMID 17660749, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ser7
    Names
    CG2045-PA
    Ser7-PA
    serine protease 2
    NP_572582.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      9865233..9867070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132354.3 → NP_572582.1  Ser7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572582.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W314
      Related
      FBpp0071322
      Conserved Domains (3) summary
      smart00680
      Location:29 → 74
      CLIP; Clip or disulphide knot domain
      smart00020
      Location:131 → 388
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:133 → 391
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W314 Q9W314

    Gene LinkOut

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