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    CG7054 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42643, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG7054provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038972
    Locus tag
    Dmel_CG7054
    See related
    AllianceGenome:FB:FBgn0038972
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG7054
    Summary
    Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in adult abdomen; adult head; organism; ovary; and testis. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG7054 in Genome Data Viewer
    Location:
    94A16-94A16; 3-74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22464985..22465938)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18290707..18291660)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Regulatory particle non-ATPase 7 Neighboring gene Adaptor Protein complex 2, mu subunit Neighboring gene Phosphatidylethanolamine-binding protein 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1H, 15N and 13C resonance assignments of CG7054, a new PEBP from Drosophila melanogaster. Rautureau G, et al. J Biomol NMR, 2007 Jun. PMID 17396237
    2. NMR structure of a phosphatidyl-ethanolamine binding protein from Drosophila. Rautureau GJ, et al. Proteins, 2010 May 1. PMID 20131378
    3. Expression and characterization of the PEBP homolog genes from Drosophila. Rautureau G, et al. Arch Insect Biochem Physiol, 2009 Jun. PMID 19309003
    4. Actomyosin contraction during cellularization is regulated in part by Src64 control of Actin 5C protein levels. Carter TY, et al. Genesis, 2019 Jun. PMID 30974046
    5. During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay. Katsuyama T, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25902518, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study confirms that CG7054 belongs to the PEBP family with the same overall fold as mammalian phosphatidyl-ethanolamine-binding protein.
      Title: NMR structure of a phosphatidyl-ethanolamine binding protein from Drosophila.
    2. CG7054 was not expressed in embryos, but was expressed in larvae and adults.
      Title: Expression and characterization of the PEBP homolog genes from Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG7054-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22464985..22465938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142793.3 → NP_651050.1  uncharacterized protein Dmel_CG7054 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651050.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD02
      Related
      FBpp0083647
      Conserved Domains (1) summary
      cd00866
      Location:15 → 164
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD02 Q9VD02

    Gene LinkOut

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