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    beta'COP Coat Protein (coatomer) beta' [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45757, updated on 9-Dec-2024

    Summary

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    Official Symbol
    beta'COPprovided by FlyBase
    Official Full Name
    Coat Protein (coatomer) beta'provided by FlyBase
    Primary source
    FLYBASE:FBgn0025724
    Locus tag
    Dmel_CG6699
    See related
    AllianceGenome:FB:FBgn0025724
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta'-COP; beta'Cop; CG6699; COPIbeta'; dbeta'COP; Dmel\CG6699
    Summary
    Predicted to enable structural molecule activity. Involved in regulation of lipid storage. Located in Golgi stack. Part of COPI vesicle coat. Is expressed in adult head. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 19. Orthologous to human COPB2 (COPI coat complex subunit beta 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See beta'COP in Genome Data Viewer
    Location:
    34B9-34B9; 2-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13378902..13382382)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13378902..13382382)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene loquacious Neighboring gene antisense RNA:CR44599 Neighboring gene Inhibitor of growth family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Schlesinger A, et al. Dev Cell, 2004 Oct. PMID 15469842
    2. COPI activity coupled with fatty acid biosynthesis is required for viral replication. Cherry S, et al. PLoS Pathog, 2006 Oct. PMID 17040126, Free PMC Article
    3. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Kim JC, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21933960, Free PMC Article
    4. In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity. Stempfle D, et al. Mol Cell Biol, 2010 Jul. PMID 20421416, Free PMC Article
    5. Expression of COPI components during development of Drosophila melanogaster. Grieder NC, et al. Gene Expr Patterns, 2005 Dec. PMID 16169286

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of membrane coat IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coat protein (coatomer) beta'
    Names
    CG6699-PA
    COPI beta' subunit
    beta'-coatomer protein
    beta'COP-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13378902..13382382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080097.4 → NP_524836.2  coat protein (coatomer) beta' [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524836.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62621, Q3KN33, Q8MRM3, Q9VJZ0
      Related
      FBpp0080048
      Conserved Domains (4) summary
      COG2319
      Location:8 → 378
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:8 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam04053
      Location:321 → 765
      Coatomer_WDAD; Coatomer WD associated region
      sd00039
      Location:20 → 55
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62621.2 O62621

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