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    papi papi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33401, updated on 9-Dec-2024

    Summary

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    Official Symbol
    papiprovided by FlyBase
    Official Full Name
    papiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031401
    Locus tag
    Dmel_CG7082
    See related
    AllianceGenome:FB:FBgn0031401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7082; CG7082; Dmel\CG7082; Papi; PAPI
    Summary
    Predicted to enable RNA binding activity. Involved in primary piRNA processing and retrotransposon silencing. Located in P granule. Part of protein-containing complex. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; germline cell; gonad; and gut section. Used to study azoospermia. Orthologous to human TDRKH (tudor and KH domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See papi in Genome Data Viewer
    Location:
    22D4-22D4; 2-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2220748..2225544)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2220748..2225544)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene missing oocyte Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44114 Neighboring gene sauron

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural insights into the sequence-specific recognition of Piwi by Drosophila Papi. Zhang Y, et al. Proc Natl Acad Sci U S A, 2018 Mar 27. PMID 29531043, Free PMC Article
    2. Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila. Ku HY, et al. PLoS Genet, 2016 Jan. PMID 26808625, Free PMC Article
    3. Genetic and mechanistic diversity of piRNA 3'-end formation. Hayashi R, et al. Nature, 2016 Nov 24. PMID 27851737, Free PMC Article
    4. Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity. Darricarrère N, et al. Proc Natl Acad Sci U S A, 2013 Jan 22. PMID 23297219, Free PMC Article
    5. A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals. Gainetdinov I, et al. Mol Cell, 2018 Sep 6. PMID 30193099, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P granule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary piRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    papi
    Names
    CG7082-PA
    CG7082-PB
    CG7082-PC
    CG7082-PD
    papi-PA
    papi-PB
    papi-PC
    papi-PD
    partner of PIWIs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2220748..2225544
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164461.2 → NP_722773.1  papi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722773.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077508
      Conserved Domains (3) summary
      cd00105
      Location:68 → 127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138 → 201
      KH_1; KH domain
      pfam00567
      Location:257 → 386
      TUDOR; Tudor domain

    2. NM_134813.3 → NP_608657.1  papi, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608657.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077509
      Conserved Domains (3) summary
      cd00105
      Location:68 → 127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138 → 201
      KH_1; KH domain
      pfam00567
      Location:257 → 386
      TUDOR; Tudor domain

    3. NM_164462.2 → NP_722774.1  papi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722774.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077510
      Conserved Domains (3) summary
      cd00105
      Location:68 → 127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138 → 201
      KH_1; KH domain
      pfam00567
      Location:257 → 386
      TUDOR; Tudor domain

    4. NM_164463.2 → NP_722775.1  papi, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722775.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VQ91
      Related
      FBpp0077511
      Conserved Domains (3) summary
      cd00105
      Location:68 → 127
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:138 → 201
      KH_1; KH domain
      pfam00567
      Location:257 → 386
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ91.1 Q9VQ91

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