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    Sec10 Secretory 10 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec10provided by FlyBase
    Official Full Name
    Secretory 10provided by FlyBase
    Primary source
    FLYBASE:FBgn0266673
    Locus tag
    Dmel_CG6159
    See related
    AllianceGenome:FB:FBgn0266673
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6159; Dmel\CG6159; dsec10; dSec10; P71; sec10; Sec10p
    Summary
    Enables beta-catenin binding activity. Involved in symbiont entry into host cell. Part of exocyst. Is expressed in adult head; embryonic neuroblast; embryonic/larval midgut; and organism. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sec10 in Genome Data Viewer
    Location:
    95E1-95E1; 3-83 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24134831..24137538)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19960553..19963260)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rootletin Neighboring gene Glutamyl-tRNA amidotransferase, subunit B Neighboring gene Tsc1 Neighboring gene Niemann-Pick type C-2f Neighboring gene Kallmann syndrome 1 Neighboring gene Seryl-tRNA synthetase-like insect mitochondrial protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila sec10 is required for hormone secretion but not general exocytosis or neurotransmission. Andrews HK, et al. Traffic, 2002 Dec. PMID 12453153
    2. Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization. Yatsenko AS, et al. Elife, 2021 Feb 23. PMID 33620318, Free PMC Article
    3. The exocyst functions in niche cells to promote germline stem cell differentiation by directly controlling EGFR membrane trafficking. Mao Y, et al. Development, 2019 Jun 28. PMID 31142545, Free PMC Article
    4. The exocyst complex is required for developmental and regenerative neurite growth in vivo. Swope RD, et al. Dev Biol, 2022 Dec. PMID 36162553, Free PMC Article
    5. The exocyst subunit Sec15 is critical for proper synaptic development and function at the Drosophila NMJ. Kang CJ, et al. Mol Cell Neurosci, 2024 Mar. PMID 38086519

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter secretion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in symbiont entry into host cell HMP PubMed 
    involved_in synaptic vesicle docking NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle targeting NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exocyst ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    secretory 10
    Names
    CG6159-PA
    Sec10 ortholog
    Sec10-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24134831..24137538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142961.5 → NP_651218.1  secretory 10 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651218.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95TZ8, Q9XTM1
      UniProtKB/TrEMBL
      Q6IDG3, S5MHR4
      Related
      FBpp0083932
      Conserved Domains (2) summary
      pfam07393
      Location:89 → 705
      Sec10; Exocyst complex component Sec10
      cl23720
      Location:46 → 103
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XTM1.1 Q9XTM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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