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    Esyt2 Extended synaptotagmin-like protein 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42929, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esyt2provided by FlyBase
    Official Full Name
    Extended synaptotagmin-like protein 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0266758
    Locus tag
    Dmel_CG6643
    See related
    AllianceGenome:FB:FBgn0266758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6643; dEsyt; dESyt; Dmel\CG6643; E-Syt2; Esyt; Tricalbin
    Summary
    Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in intracellular transport and synaptic vesicle exocytosis. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head and adult heart. Orthologous to human ESYT1 (extended synaptotagmin 1); ESYT2 (extended synaptotagmin 2); and ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Esyt2 in Genome Data Viewer
    Location:
    96A7-96A7; 3-85 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24544719..24556549)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20370441..20382271)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene anastral spindle 1 Neighboring gene CF transmembrane conductance regulator Neighboring gene transfer RNA:Aspartic acid-GTC 1-11 Neighboring gene small nuclear RNA U6 at 96A a Neighboring gene small nuclear RNA U6 at 96A b Neighboring gene small nuclear RNA U6 at 96A c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila. Kikuma K, et al. Genetics, 2017 Nov. PMID 28882990, Free PMC Article
    2. Emerging perspectives on multidomain phosphatidylinositol transfer proteins. Raghu P, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 Sep. PMID 34098114, Free PMC Article
    3. Extended synaptotagmin regulates membrane contact site structure and lipid transfer function in vivo. Nath VR, et al. EMBO Rep, 2020 Sep 3. PMID 32716137, Free PMC Article
    4. Astrocyte Ca(2+) Influx Negatively Regulates Neuronal Activity. Zhang YV, et al. eNeuro, 2017 Mar-Apr. PMID 28303263, Free PMC Article
    5. Glial ER and GAP junction mediated Ca(2+) waves are crucial to maintain normal brain excitability. Weiss S, et al. Glia, 2022 Jan. PMID 34528727, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Esyt localizes to presynaptic ER structures at the neuromuscular junction and promotes neurotransmission and synaptic growth.
      Title: Extended Synaptotagmin Localizes to Presynaptic ER and Promotes Neurotransmission and Synaptic Growth in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular transport ISM
    Inferred from Sequence Model
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    extended synaptotagmin-like protein 2
    Names
    CG6643-PA
    CG6643-PB
    CG6643-PC
    CG6643-PD
    Esyt2-PA
    Esyt2-PB
    Esyt2-PC
    Esyt2-PD
    extended synaptotagmin-like protein 2 ortholog
    tricalbin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24544719..24556549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170652.2 → NP_733010.1  extended synaptotagmin-like protein 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733010.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH8, Q9VC62
      Related
      FBpp0084031
      Conserved Domains (4) summary
      cd04024
      Location:315 → 434
      C2A_Synaptotagmin-like; C2 domain first repeat present in Synaptotagmin-like proteins
      cd04030
      Location:682 → 810
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:463 → 568
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      pfam17047
      Location:121 → 299
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    2. NM_170653.3 → NP_733011.2  extended synaptotagmin-like protein 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733011.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9UNH8, Q7KS16
      Related
      FBpp0084032
      Conserved Domains (4) summary
      cd04024
      Location:348 → 467
      C2A_Synaptotagmin-like; C2 domain first repeat present in Synaptotagmin-like proteins
      cd04030
      Location:715 → 843
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:496 → 601
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      pfam17047
      Location:154 → 332
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    3. NM_001260358.2 → NP_001247287.1  extended synaptotagmin-like protein 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247287.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6F9, A9UNH8
      Conserved Domains (4) summary
      cd04024
      Location:348 → 471
      C2A_Synaptotagmin-like; C2 domain first repeat present in Synaptotagmin-like proteins
      cd04030
      Location:719 → 847
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:500 → 605
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      pfam17047
      Location:154 → 332
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    4. NM_001275992.1 → NP_001262921.1  extended synaptotagmin-like protein 2, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262921.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGU9, A9UNH8
      Conserved Domains (4) summary
      cd04024
      Location:348 → 467
      C2A_Synaptotagmin-like; C2 domain first repeat present in Synaptotagmin-like proteins
      cd04030
      Location:712 → 840
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:496 → 601
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      pfam17047
      Location:154 → 332
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6F9 A0A0B4K6F9
    A0A0B4KGU9 A0A0B4KGU9
    Q7KS16 Q7KS16
    Q8IH66 Q8IH66
    Q961I7 Q961I7
    Q9VC62 Q9VC62

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