inaC inactivation no afterpotential C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: inaCprovided by FlyBase
Official Full Name: inactivation no afterpotential Cprovided by FlyBase
Primary source: FLYBASE:FBgn0004784
Locus tag: Dmel_CG6518
See related: AllianceGenome:FB:FBgn0004784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6518; Dmel\CG6518; Dpkc2; dPKC53E; dPKC53E(ey); ePKC; eye PKC; eye-PKC; eyePKC; inac; InaC; INAC; PK-C; PKC; PKC 53E; pkc-2; Pkc2; PKC2; PKCi; PKCinac
Summary: Predicted to enable calcium,diacylglycerol-dependent serine/threonine kinase activity. Involved in several processes, including detection of light stimulus; phospholipase C-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of clathrin-dependent endocytosis. Located in rhabdomere. Colocalizes with endosome. Is expressed in several structures, including head; lamina; photoreceptor; rhabdomere; and spermatozoon. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in carcinoma (multiple); dilated cardiomyopathy; high grade glioma (multiple); ovarian cancer; and spinocerebellar ataxia type 14. Orthologous to human PRKCA (protein kinase C alpha); PRKCB (protein kinase C beta); and PRKCG (protein kinase C gamma). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 53E1-53E1; 2-81 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (16898535..16901575)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (12786040..12789080)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium,diacylglycerol-dependent serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of light stimulus involved in sensory perception	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female gonad development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of opsin-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of opsin-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of clathrin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with endosome	IDA Inferred from Direct Assay more info	PubMed
part_of inaD signaling complex	TAS Traceable Author Statement more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactivation no afterpotential C

Names: CG6518-PA; PKC-eye; Protein-kinase-2; eye-PKC; eye-protein-kinase C; eye-specific PKC; inaC-PA; protein kinase C; protein kinase-c2; protein-kinase-C

NP_476863.1

EC 2.7.11.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

16898535..16901575

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_057515.3 → NP_476863.1 inactivation no afterpotential C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476863.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P13677, Q9V7V5

Related

FBpp0086196

Conserved Domains (4) summary

cd04026
Location:194 → 324

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:371 → 629

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05570
Location:375 → 692

STKc_PKC; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C

pfam00130
Location:72 → 124

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)