TER94 Transitional endoplasmic reticulum 94 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TER94provided by FlyBase
Official Full Name: Transitional endoplasmic reticulum 94provided by FlyBase
Primary source: FLYBASE:FBgn0286784
Locus tag: Dmel_CG2331
See related: AllianceGenome:FB:FBgn0286784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: (VCP)/p97; 22.26; 7.12; anon-WO2004063362.65; anon-WO2004063362.67; Apple; BcDNA.GM02885; BcDNA:GM02885; cdc48; CDC48; CG2331; Dmel\CG2331; DmTER94; dmTERA; dTERA; dvcp; dVCP; I; l(2)03775; l(2)46CFf; l(2)46CFs; l(2)46Ch; l(2)46Db; p97; pTER94; Q7KN62; Ter 94; ter94; Ter94; Tera; vcp; Vcp; VCP; VCP ATPase; VCP/p97; VCP1; VIII
Summary: Enables protein sequestering activity. Involved in several processes, including larval midgut cell programmed cell death; macroautophagy; and negative regulation of signal transduction. Located in P granule; fusome; and lysosome. Is active in cytosol. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; germline cell; gonad; and mesoderm. Used to study frontotemporal dementia; inclusion body myopathy with Paget disease of bone and frontotemporal dementia (multiple); neurodegenerative disease (multiple); and primary ovarian insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; frontotemporal dementia and/or amyotrophic lateral sclerosis 6; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 46D1-46D1; 2-61 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9989159..9993559)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5876664..5881064)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway.
Title: The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway.
CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
Title: CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases.
VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila.
Title: VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila.
VCP Machinery Mediates Autophagic Degradation of Empty Argonaute.
Title: VCP Machinery Mediates Autophagic Degradation of Empty Argonaute.
rescue experiments with a lethal mfap1 mutant show that the VCP binding region is not essential for Mfap1 function, but may act to increase its stability or activity
Title: The spliceosome-associated protein Mfap1 binds to VCP in Drosophila.
Clu is upstream of and binds to VCP in vivo and promotes VCP-dependent Marf degradation in vitro Marf accumulates in whole muscle lysates of clu-deficient flies and is destabilized upon Clu overexpression. Thus, Clu is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP for Marf degradation to promote damaged mitochondrial clearance.
Title: Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation.
results have revealed SUMOylation as a molecular signaling switch to regulate the distribution and functions of VCP during stress response, and suggest that deficiency in VCP SUMOylation caused by pathogenic mutations will render cells vulnerable to stress insults.
Title: Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.
The authors propose that VCP sustains sarcoplasmic proteostasis, in part, by controlling the integrity of a dynamic tubular lysosomal network.
Title: VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo.
Ter94/VCP appears to be an evolutionarily conserved component that regulates BMP-Smad1/5/8 signaling.
Title: Ter94/VCP is a novel component involved in BMP signaling.
Data identifies that ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS
Title: Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum membrane fusion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in endoplasmic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in P granule	IDA Inferred from Direct Assay more info	PubMed
part_of VCP-NPL4-UFD1 AAA ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	HDA more info	PubMed

General protein information

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Preferred Names: transitional endoplasmic reticulum 94

Names: CG2331-PA; CG2331-PC; CG2331-PD; CG2331-PE; TER94-PA; TER94-PC; TER94-PD; TER94-PE; TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE TER94; Ter94; VCP; Valosin-Containing protein; complementation group I; group VIII; lethal (2) 46Db; p97; p97 ATPase; transitional endoplasmic reticulum ATPase; valosin containing protein

NP_001097249.1

EC 3.-.-.-

NP_001097250.1

EC 3.-.-.-

NP_001286261.1

EC 3.-.-.-

unusual splice

NP_477369.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9989159..9993559

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058021.4 → NP_477369.1 transitional endoplasmic reticulum 94, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477369.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A8DY85, A8DY86, O76279, Q7KN62, Q9U463

UniProtKB/TrEMBL

D0IQG4

Related

FBpp0087479

Conserved Domains (5) summary

smart01072
Location:128 → 188

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:22 → 762

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:238 → 367

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:22 → 104

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:716 → 758

Vps4_C; Vps4 C terminal oligomerization domain
NM_001103780.2 → NP_001097250.1 transitional endoplasmic reticulum 94, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097250.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQG4

Conserved Domains (5) summary

smart01072
Location:86 → 146

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:1 → 720

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:196 → 325

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:1 → 62

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:674 → 716

Vps4_C; Vps4 C terminal oligomerization domain
NM_001103779.2 → NP_001097249.1 transitional endoplasmic reticulum 94, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097249.1

Status: REVIEWED

UniProtKB/TrEMBL

D0IQG4

Conserved Domains (5) summary

smart01072
Location:153 → 213

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:47 → 787

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:263 → 392

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:47 → 129

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:741 → 783

Vps4_C; Vps4 C terminal oligomerization domain
NM_001299332.1 → NP_001286261.1 transitional endoplasmic reticulum 94, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286261.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFZ4, D0IQG4

Conserved Domains (5) summary

smart01072
Location:153 → 213

CDC48_2; Cell division protein 48 (CDC48) domain 2

TIGR01243
Location:47 → 786

CDC48; AAA family ATPase, CDC48 subfamily

pfam00004
Location:263 → 392

AAA; ATPase family associated with various cellular activities (AAA)

pfam02359
Location:47 → 129

CDC48_N; Cell division protein 48 (CDC48), N-terminal domain

pfam09336
Location:751 → 782

Vps4_C; Vps4 C terminal oligomerization domain