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    CG8545 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36365, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8545provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033741
    Locus tag
    Dmel_CG8545
    See related
    AllianceGenome:FB:FBgn0033741
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8545; Nol1Nt; NOP2
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Predicted to be involved in maturation of LSU-rRNA and rRNA base methylation. Predicted to be active in nucleolus. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human NOP2 (NOP2 nucleolar protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8545 in Genome Data Viewer
    Location:
    49A7-49A7; 2-67 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12468651..12471722)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (8356156..8359227)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dystrobrevin Neighboring gene uncharacterized protein Neighboring gene Lachesin Neighboring gene dim gamma-tubulin 5 Neighboring gene Neprilysin-like 10 Neighboring gene Diuretic hormone 44 receptor 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. Cakouros D, et al. J Cell Biol, 2008 Aug 11. PMID 18695041, Free PMC Article
    2. An SMN-dependent U12 splicing event essential for motor circuit function. Lotti F, et al. Cell, 2012 Oct 12. PMID 23063131, Free PMC Article
    3. The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila. Rollmann SM, et al. Genetics, 2007 Jun. PMID 17435226, Free PMC Article
    4. Drosophila TGIF is essential for developmentally regulated transcription in spermatogenesis. Ayyar S, et al. Development, 2003 Jul. PMID 12756169
    5. Regulation of Ribosome Biogenesis and Protein Synthesis Controls Germline Stem Cell Differentiation. Sanchez CG, et al. Cell Stem Cell, 2016 Feb 4. PMID 26669894, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8545-PA
    NP_610786.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12468651..12471722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136942.3 → NP_610786.2  uncharacterized protein Dmel_CG8545 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610786.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z909
      Related
      FBpp0087045
      Conserved Domains (3) summary
      TIGR00446
      Location:363 → 637
      nop2p; NOL1/NOP2/sun family putative RNA methylase
      pfam01189
      Location:428 → 636
      Nol1_Nop2_Fmu; 16S rRNA methyltransferase RsmF
      pfam17125
      Location:333 → 424
      Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z909 A1Z909
    Q8T9K3 Q8T9K3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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