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    Idi Isopentenyl-diphosphate delta isomerase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42526, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idiprovided by FlyBase
    Official Full Name
    Isopentenyl-diphosphate delta isomeraseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038876
    Locus tag
    Dmel_CG5919
    See related
    AllianceGenome:FB:FBgn0038876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5919; Dmel\CG5919; IDI1; IDI1/2; IPPI
    Summary
    Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Predicted to be involved in isopentenyl diphosphate biosynthetic process. Predicted to be located in peroxisome. Predicted to be active in cytoplasm. Is expressed in organism. Orthologous to several human genes including IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Idi in Genome Data Viewer
    Location:
    93D2-93D2; 3-71 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21270126..21271408)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17095848..17097130)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45798 Neighboring gene Rab1 Neighboring gene Adaptor Protein complex 2, sigma subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene SIFamide receptor Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. σ2-Adaptin Facilitates Basal Synaptic Transmission and Is Required for Regenerating Endo-Exo Cycling Pool Under High-Frequency Nerve Stimulation in Drosophila. Choudhury SD, et al. Genetics, 2016 May. PMID 26920756, Free PMC Article
    2. Integrated multi-omics analysis of RB-loss identifies widespread cellular programming and synthetic weaknesses. Rajasekaran S, et al. Commun Biol, 2021 Aug 17. PMID 34404904, Free PMC Article
    3. Isoprenoids control germ cell migration downstream of HMGCoA reductase. Santos AC, et al. Dev Cell, 2004 Feb. PMID 14960281
    4. Inhibition of mevalonate pathway by macrophage-specific delivery of atorvastatin prevents their pro-inflammatory polarisation. Krejčová G, et al. Insect Mol Biol, 2024 Aug. PMID 38367277
    5. PRE-mediated bypass of two Su(Hw) insulators targets PcG proteins to a downstream promoter. Comet I, et al. Dev Cell, 2006 Jul. PMID 16824958

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables isopentenyl-diphosphate delta-isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in isopentenyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Isopentenyl-diphosphate delta isomerase
    Names
    CG5919-PA
    CG5919-PB
    Idi-PA
    Idi-PB
    NP_001163673.1
    NP_650962.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21270126..21271408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142705.3 → NP_650962.1  Isopentenyl-diphosphate delta isomerase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650962.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APV5, Q8MRH1, Q9VDC2
      Related
      FBpp0083457
      Conserved Domains (2) summary
      COG1443
      Location:49 → 233
      Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
      cl00447
      Location:48 → 256
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. NM_001170202.2 → NP_001163673.1  Isopentenyl-diphosphate delta isomerase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0APV5, Q8MRH1, Q9VDC2
      Conserved Domains (2) summary
      COG1443
      Location:49 → 233
      Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
      cl00447
      Location:48 → 256
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MRH1 Q8MRH1
    Q9VDC2 Q9VDC2

    Gene LinkOut

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