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    CG4853 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4853provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034230
    Locus tag
    Dmel_CG4853
    See related
    AllianceGenome:FB:FBgn0034230
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4853
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of Ras protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4853 in Genome Data Viewer
    Location:
    54C1-54C1; 2-83 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17514217..17517445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13401722..13404950)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cathepsin K2 Neighboring gene Anaphase Promoting Complex subunit 10 Neighboring gene patronin Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cost-effective strategies for completing the interactome. Schwartz AS, et al. Nat Methods, 2009 Jan. PMID 19079254, Free PMC Article
    2. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
    3. Complexities of recapitulating polygenic effects in natural populations: replication of genetic effects on wing shape in artificially selected and wild-caught populations of Drosophila melanogaster. Pelletier K, et al. Genetics, 2023 Jul 6. PMID 36961731, Free PMC Article
    4. Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Kobayashi M, et al. Proc Natl Acad Sci U S A, 2006 Sep 26. PMID 16971484, Free PMC Article
    5. Evolutionary expansion of the Ras switch regulatory module in eukaryotes. Díez D, et al. Nucleic Acids Res, 2011 Jul. PMID 21447561, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Ras protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4853-PA
    CG4853-PB
    CG4853-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17514217..17517445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137378.4 → NP_611222.2  uncharacterized protein Dmel_CG4853, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611222.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAU6, Q95S44
      Related
      FBpp0086095
      Conserved Domains (2) summary
      pfam00617
      Location:438 → 638
      RasGEF; RasGEF domain
      pfam00618
      Location:288 → 365
      RasGEF_N; RasGEF N-terminal motif

    2. NM_166238.4 → NP_725689.2  uncharacterized protein Dmel_CG4853, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725689.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZAU6, Q95S44
      Related
      FBpp0086094
      Conserved Domains (2) summary
      pfam00617
      Location:438 → 638
      RasGEF; RasGEF domain
      pfam00618
      Location:288 → 365
      RasGEF_N; RasGEF N-terminal motif

    3. NM_001299606.1 → NP_001286535.1  uncharacterized protein Dmel_CG4853, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFJ8, Q95S44
      Conserved Domains (2) summary
      pfam00617
      Location:433 → 633
      RasGEF; RasGEF domain
      pfam00618
      Location:283 → 360
      RasGEF_N; RasGEF N-terminal motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LFJ8 A0A0B4LFJ8
    A1ZAU6 A1ZAU6
    Q86PC5 Q86PC5
    Q95S44 Q95S44

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