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    CG2100 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2100provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037369
    Locus tag
    Dmel_CG2100
    See related
    AllianceGenome:FB:FBgn0037369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2100
    Summary
    Predicted to enable CCA tRNA nucleotidyltransferase activity and tRNA binding activity. Predicted to be involved in mitochondrial tRNA 3'-end processing and tRNA 3'-terminal CCA addition. Predicted to be active in mitochondrion. Is expressed in organism. Human ortholog(s) of this gene implicated in sideroblastic anemia with B-cell immunodeficiency, periodic fevers, and developmental delay. Orthologous to human TRNT1 (tRNA nucleotidyl transferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2100 in Genome Data Viewer
    Location:
    83C1-83C1; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5734698..5736355, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1560420..1562077, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene castor Neighboring gene long non-coding RNA:CR44924 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Symplekin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Tatomer DC, et al. Nucleus, 2014. PMID 25493544, Free PMC Article
    2. The role of Dichaete in transcriptional regulation during Drosophila embryonic development. Aleksic J, et al. BMC Genomics, 2013 Dec 8. PMID 24314314, Free PMC Article
    3. Genome-wide analysis of self-renewal in Drosophila neural stem cells by transgenic RNAi. Neumüller RA, et al. Cell Stem Cell, 2011 May 6. PMID 21549331, Free PMC Article
    4. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article
    5. Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Phanse S, et al. Data Brief, 2016 Mar. PMID 26870755, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables CCA tRNA nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial tRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 3'-terminal CCA addition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2100-PA
    CG2100-PB
    NP_001163512.1
    NP_649578.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5734698..5736355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170041.2 → NP_001163512.1  uncharacterized protein Dmel_CG2100, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163512.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNH2
      Conserved Domains (3) summary
      cd05398
      Location:73 → 210
      NT_ClassII-CCAase; Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes
      COG0617
      Location:71 → 465
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
      pfam12627
      Location:248 → 302
      PolyA_pol_RNAbd; Probable RNA and SrmB- binding site of polymerase A

    2. NM_141321.4 → NP_649578.1  uncharacterized protein Dmel_CG2100, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNH2
      Related
      FBpp0078373
      Conserved Domains (3) summary
      cd05398
      Location:73 → 210
      NT_ClassII-CCAase; Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes
      COG0617
      Location:71 → 465
      PcnB; tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]
      pfam12627
      Location:248 → 302
      PolyA_pol_RNAbd; Probable RNA and SrmB- binding site of polymerase A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P00 Q86P00
    Q9VNH2 Q9VNH2

    Gene LinkOut

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