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    SmD2 Small ribonucleoprotein particle protein SmD2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SmD2provided by FlyBase
    Official Full Name
    Small ribonucleoprotein particle protein SmD2provided by FlyBase
    Primary source
    FLYBASE:FBgn0261789
    Locus tag
    Dmel_CG1249
    See related
    AllianceGenome:FB:FBgn0261789
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD03002; CG1249; D2-Sm; dD2; Dmel\CG1249; Smd2; SMD2_DROME; snRNP D2; snRNP2
    Summary
    Predicted to enable RNA binding activity. Involved in mitotic cell cycle. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human SNRPD2 (small nuclear ribonucleoprotein D2 polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SmD2 in Genome Data Viewer
    Location:
    83E4-83E4; 3-47.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6345000..6345911, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2170722..2171633, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 83

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. Azzouz TN, et al. RNA, 2003 Dec. PMID 14624008, Free PMC Article
    2. Deletions of singular U1 snRNA gene significantly interfere with transcription and 3'-end mRNA formation. Wang M, et al. PLoS Genet, 2023 Nov. PMID 37917726, Free PMC Article
    3. Novel interactors of the Drosophila Survival Motor Neuron (SMN) Complex suggest its full conservation. Lanfranco M, et al. FEBS Lett, 2017 Nov. PMID 28949413
    4. A Drosophila toolkit for HA-tagged proteins unveils a block in autophagy flux in the last instar larval fat body. Murakawa T, et al. Development, 2022 Mar 15. PMID 35319746
    5. SmD1 Modulates the miRNA Pathway Independently of Its Pre-mRNA Splicing Function. Xiong XP, et al. PLoS Genet, 2015 Aug. PMID 26308709, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alternative mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle HMP PubMed 
    involved_in spliceosomal snRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of U1 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U11/U12 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pICln-Sm protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small nuclear ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small nuclear ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribonucleoprotein particle protein SmD2
    Names
    CG1249-PA
    SmD2-PA
    small ribonucleoprotein particle protein D2
    snRNP2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6345000..6345911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141388.4 → NP_649645.1  small ribonucleoprotein particle protein SmD2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649645.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VI10
      UniProtKB/TrEMBL
      A0A1B2AJC2
      Related
      FBpp0081234
      Conserved Domains (1) summary
      cd01720
      Location:23 → 112
      Sm_D2; Sm protein D2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI10.1 Q9VI10

    Gene LinkOut

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