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    Df31 Decondensation factor 31 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35418, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Df31provided by FlyBase
    Official Full Name
    Decondensation factor 31provided by FlyBase
    Primary source
    FLYBASE:FBgn0022893
    Locus tag
    Dmel_CG2207
    See related
    AllianceGenome:FB:FBgn0022893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1A4; anon-EST:Liang-1.46; anon-EST:Posey126; anon-WO0153538.53; anon1A4; BEST:LD04967; CG2207; clone 1.46; DF 31; DF31; Dmel\CG2207; l(2)k05815; LD04967
    Summary
    Enables histone binding activity. Involved in nucleosome assembly. Located in chromatin and nucleus. Colocalizes with polytene chromosome. Is expressed in several structures, including central brain primordium; embryonic brain; larval nervous system; ventral nerve cord; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Df31 in Genome Data Viewer
    Location:
    39E3-39E3; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21626309..21629932, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21626309..21629932, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43148 Neighboring gene long non-coding RNA:CR44993 Neighboring gene Adenylate cyclase 3 Neighboring gene long non-coding RNA:CR43144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DF 31, a sperm decondensation factor from Drosophila melanogaster: purification and characterization. Crevel G, et al. EMBO J, 1995 Apr 18. PMID 7737122, Free PMC Article
    2. Changes in higher order structures of chromatin by RNP complexes. Schubert T, et al. RNA Biol, 2013 Feb. PMID 23353578, Free PMC Article
    3. Intrinsic structural disorder of DF31, a Drosophila protein of chromatin decondensation and remodeling activities. Szollosi E, et al. J Proteome Res, 2008 Jun. PMID 18484763
    4. The Drosophila Df31 protein interacts with histone H3 tails and promotes chromatin bridging in vitro. Guillebault D, et al. J Mol Biol, 2007 Nov 2. PMID 17889901
    5. Df31 is a novel nuclear protein involved in chromatin structure in Drosophila melanogaster. Crevel G, et al. J Cell Sci, 2001 Jan. PMID 11112688

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The binding of the Df31-snoRNA complex to chromatin results in the opening and the maintenance of accessible higher order structures of chromatin.
      Title: Changes in higher order structures of chromatin by RNP complexes.
    2. Data indicate that the interaction between Df31 and chromatin is RNA dependent.
      Title: Df31 protein and snoRNAs maintain accessible higher-order structures of chromatin.
    3. Df31 is intrinsically disordered along its entire length. Df31 is a monomeric protein, which function may benefit from having an extended and highly flexible structural state.
      Title: Intrinsic structural disorder of DF31, a Drosophila protein of chromatin decondensation and remodeling activities.
    4. Results show that the Drosophila Df31 protein interacts with histone H3 tails and promotes interstrand bridging between two independent oligonucleosome chains.
      Title: The Drosophila Df31 protein interacts with histone H3 tails and promotes chromatin bridging in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleosome assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    decondensation factor 31
    Names
    CG2207-PA
    CG2207-PB
    CG2207-PF
    Df31-PA
    Df31-PB
    Df31-PF
    anon-fast-evolving-1A4
    chromatin decondensation factor 31

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21626309..21629932 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001032217.3 → NP_001027388.1  decondensation factor 31, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027388.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16043

    2. NM_165388.4 → NP_724350.1  decondensation factor 31, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16043
      Related
      FBpp0085274

    3. NM_078890.4 → NP_523614.1  decondensation factor 31, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16043
      Related
      FBpp0085273
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16043 O16043

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