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    CG3107 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG3107provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0033005
    Locus tag
    Dmel_CG3107
    See related
    AllianceGenome:FB:FBgn0033005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG3107
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in mitochondrial matrix. Is expressed in adult head; adult heart; embryonic/larval midgut; larval muscle system; and organism. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 30. Orthologous to human PITRM1 (pitrilysin metallopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3107 in Genome Data Viewer
    Location:
    41D3-41D3; 2-55 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5090581..5095090)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (978086..982595)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Troponin C at 41C Neighboring gene pseudo Neighboring gene long non-coding RNA:CR43256 Neighboring gene gustavus Neighboring gene Atf6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. Thomas RE, et al. PLoS Genet, 2014. PMID 24874806, Free PMC Article
    2. Genetic analysis of RpL38 and RpL5, two minute genes located in the centric heterochromatin of chromosome 2 of Drosophila melanogaster. Marygold SJ, et al. Genetics, 2005 Feb. PMID 15520262, Free PMC Article
    3. Genetic and bioinformatic analysis of 41C and the 2R heterochromatin of Drosophila melanogaster: a window on the heterochromatin-euchromatin junction. Myster SH, et al. Genetics, 2004 Feb. PMID 15020470, Free PMC Article
    4. Cytogenetic and molecular characterization of heterochromatin gene models in Drosophila melanogaster. Rossi F, et al. Genetics, 2007 Feb. PMID 17110485, Free PMC Article
    5. The paradox of functional heterochromatin. Dimitri P, et al. Bioessays, 2005 Jan. PMID 15612038

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 5090963-5091086 mobile_element_type = transposon:INE-1{}2068

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3107-PA
    CG3107-PB
    CG3107-PC
    CG3107-PD
    NP_001036470.1
    NP_001286139.1
    NP_610156.1
    NP_724396.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      5090581..5095090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165416.2 → NP_724396.1  uncharacterized protein Dmel_CG3107, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724396.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ44, B7YZR1, Q0E9P8, Q9V9E3
      UniProtKB/TrEMBL
      A0A0B4LES3
      Related
      FBpp0085414
      Conserved Domains (4) summary
      COG1026
      Location:68 → 1003
      Cym1; Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:120 → 177
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:268 → 457
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam08367
      Location:531 → 773
      M16C_assoc; Peptidase M16C associated

    2. NM_136312.2 → NP_610156.1  uncharacterized protein Dmel_CG3107, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610156.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ44, B7YZR1, Q0E9P8, Q9V9E3
      UniProtKB/TrEMBL
      A0A0B4LES3
      Related
      FBpp0085413
      Conserved Domains (4) summary
      COG1026
      Location:68 → 1003
      Cym1; Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:120 → 177
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:268 → 457
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam08367
      Location:531 → 773
      M16C_assoc; Peptidase M16C associated

    3. NM_001299210.1 → NP_001286139.1  uncharacterized protein Dmel_CG3107, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286139.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ44, B7YZR1, Q0E9P8, Q9V9E3
      UniProtKB/TrEMBL
      A0A0B4LES3
      Conserved Domains (4) summary
      COG1026
      Location:68 → 1003
      Cym1; Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:120 → 177
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:268 → 457
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam08367
      Location:531 → 773
      M16C_assoc; Peptidase M16C associated

    4. NM_001043005.2 → NP_001036470.1  uncharacterized protein Dmel_CG3107, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036470.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZ44, B7YZR1, Q0E9P8, Q9V9E3
      UniProtKB/TrEMBL
      A0A0B4LES3
      Conserved Domains (4) summary
      COG1026
      Location:68 → 1003
      Cym1; Zn-dependent peptidase, M16 (insulinase) family [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:120 → 177
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:268 → 457
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam08367
      Location:531 → 773
      M16C_assoc; Peptidase M16C associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LES3 A0A0B4LES3
    Q9V9E3.2 Q9V9E3

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