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    Bub1 Bub1 kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33758, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bub1provided by FlyBase
    Official Full Name
    Bub1 kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031696
    Locus tag
    Dmel_CG14030
    See related
    AllianceGenome:FB:FBgn0031696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bub1; BUB1; BUB1-like; CG14030; CG14030/Bub1; Dmel\CG14030
    Summary
    Predicted to enable protein kinase activity. Involved in mitotic spindle assembly checkpoint signaling. Located in centrosome. Is expressed in organism and primordial germ cell. Human ortholog(s) of this gene implicated in colorectal cancer and primary autosomal recessive microcephaly. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Bub1 in Genome Data Viewer
    Location:
    25D3-25D3; 2-16 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5278865..5283283)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5278865..5283283)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene Cytochrome P450 4ac3 Neighboring gene Ninein Neighboring gene long non-coding RNA:CR44743 Neighboring gene long non-coding RNA:CR44742 Neighboring gene long non-coding RNA:CR45730 Neighboring gene vrille

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bub1 and Bub3 regulate metabolic adaptation via macrolipophagy in Drosophila. Zhang Q, et al. Cell Rep, 2023 Apr 25. PMID 37027296
    2. Bub1 Facilitates Virus Entry through Endocytosis in a Model of Drosophila Pathogenesis. Yang S, et al. J Virol, 2018 Sep 15. PMID 29976667, Free PMC Article
    3. Different spindle checkpoint proteins monitor microtubule attachment and tension at kinetochores in Drosophila cells. Logarinho E, et al. J Cell Sci, 2004 Apr 1. PMID 15075237
    4. Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation in Drosophila oocytes. Joshi JN, et al. Mol Biol Cell, 2024 Aug 1. PMID 38865189, Free PMC Article
    5. Rod-Zw10-Zwilch: a key player in the spindle checkpoint. Karess R. Trends Cell Biol, 2005 Jul. PMID 15922598

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic sister chromatid cohesion, centromeric IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Bub1 kinase
    Names
    Bub1 homologue
    Bub1-PA
    Bub1-PB
    Bub1-PC
    CG14030-PA
    CG14030-PB
    CG14030-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5278865..5283283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298692.1 → NP_001285621.1  Bub1 kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285621.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMS5
      Conserved Domains (2) summary
      smart00777
      Location:38 → 158
      Mad3_BUB1_I; Mad3/BUB1 hoMad3/BUB1 homology region 1
      cd13981
      Location:813 → 1096
      STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1

    2. NM_001298693.1 → NP_001285622.1  Bub1 kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMS5
      Conserved Domains (2) summary
      smart00777
      Location:38 → 158
      Mad3_BUB1_I; Mad3/BUB1 hoMad3/BUB1 homology region 1
      cd13981
      Location:813 → 1096
      STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1

    3. NM_135075.4 → NP_608919.1  Bub1 kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608919.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VMS5
      Related
      FBpp0078704
      Conserved Domains (2) summary
      smart00777
      Location:38 → 158
      Mad3_BUB1_I; Mad3/BUB1 hoMad3/BUB1 homology region 1
      cd13981
      Location:813 → 1096
      STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMS5 Q9VMS5

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