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    Uch-L5 Ubiquitin carboxy-terminal hydrolase L5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uch-L5provided by FlyBase
    Official Full Name
    Ubiquitin carboxy-terminal hydrolase L5provided by FlyBase
    Primary source
    FLYBASE:FBgn0011327
    Locus tag
    Dmel_CG3431
    See related
    AllianceGenome:FB:FBgn0011327
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA.LD24440; BcDNA:LD24440; CG3431; Dmel\CG3431; dUCH37; dUCHL5; p37A; Q9XZ61; UCH; UCH 37; uch-L3; Uch-L3; uch-l5; Uch37; uchl3; Uchl3; UCHL5
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in positive regulation of smoothened signaling pathway. Located in cytoplasm and nucleus. Part of proteasome regulatory particle. Is expressed in adult head and ventral nerve cord. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Uch-L5 in Genome Data Viewer
    Location:
    67B9-67B9; 3-29 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9475493..9476965, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9468593..9470065, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Jumonji, AT rich interactive domain 2 Neighboring gene pallbearer Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin C-Terminal Hydrolase L5 Plays an Essential Role in the Fly Innate Immune Defense against Bacterial Infection. Zhang C, et al. Front Biosci (Landmark Ed), 2023 Nov 23. PMID 38062818
    2. A new method of purification of proteasome substrates reveals polyubiquitination of 20 S proteasome subunits. Ventadour S, et al. J Biol Chem, 2007 Feb 23. PMID 17189251
    3. Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson's Disease. Tran HH, et al. Sci Rep, 2018 Mar 13. PMID 29535397, Free PMC Article
    4. The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila. Jacomin AC, et al. PLoS One, 2015. PMID 26571504, Free PMC Article
    5. The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila. Farkas A, et al. Sci Rep, 2023 Dec 11. PMID 38081944, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. UCHL5 interacts with and deubiquitinates Smo, increasing stability and promoting accumulation at the cell membrane.
      Title: The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chromosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxy-terminal hydrolase L5
    Names
    CG3431-PA
    CG3431-PB
    Uch-L5-PA
    Uch-L5-PB
    ubiquitin C-terminal hydrolase
    ubiquitin C-terminal hydrolase related
    ubiquitin carboxy-terminal hydrolase L5 ortholog
    NP_001261632.1
    NP_524003.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9475493..9476965 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079279.3 → NP_524003.1  ubiquitin carboxy-terminal hydrolase L5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524003.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ61
      Related
      FBpp0076200
      Conserved Domains (1) summary
      cd09617
      Location:8 → 222
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1

    2. NM_001274703.1 → NP_001261632.1  ubiquitin carboxy-terminal hydrolase L5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261632.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XZ61
      Conserved Domains (1) summary
      cd09617
      Location:8 → 222
      Peptidase_C12_UCH37_BAP1; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families UCH37 (UCH-L5) and BAP1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XZ61 Q9XZ61

    Gene LinkOut

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