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    Patr-1 Protein associated with topo II related - 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42058, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Patr-1provided by FlyBase
    Official Full Name
    Protein associated with topo II related - 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0266053
    Locus tag
    Dmel_CG5208
    See related
    AllianceGenome:FB:FBgn0266053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.282; BcDNA:LD27979; CG5208; Dmel\CG5208; hpat; Hpat; HPat; HPat1; l(3)06442; LD27979; Part-1; patr-1
    Summary
    Predicted to enable RNA binding activity. Involved in P-body assembly; deadenylation-dependent decapping of nuclear-transcribed mRNA; and negative regulation of synaptic assembly at neuromuscular junction. Located in P-body. Is expressed in larval brain; larval ventral nerve cord; and muscle cell. Orthologous to several human genes including PATL1 (PAT1 homolog 1, processing body mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Patr-1 in Genome Data Viewer
    Location:
    89E10-89E11; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17043564..17048421)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12869286..12874143)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 7-32 Neighboring gene bedwarfed Neighboring gene Daughters against dpp Neighboring gene Nucleostemin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HPat a decapping activator interacting with the miRNA effector complex. Barišić-Jäger E, et al. PLoS One, 2013. PMID 23977167, Free PMC Article
    2. The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa. Braun JE, et al. EMBO J, 2010 Jul 21. PMID 20543818, Free PMC Article
    3. The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction. Pradhan SJ, et al. J Cell Sci, 2012 Dec 15. PMID 23097047, Free PMC Article
    4. HELZ directly interacts with CCR4-NOT and causes decay of bound mRNAs. Hanet A, et al. Life Sci Alliance, 2019 Oct. PMID 31570513, Free PMC Article
    5. RNP components condense into repressive RNP granules in the aging brain. Pushpalatha KV, et al. Nat Commun, 2022 May 19. PMID 35589695, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HPat couples mRNA deadenylation and decapping in Drosophila.
      Title: HPat a decapping activator interacting with the miRNA effector complex.
    2. HPat binds to and copurifies with GW182.
      Title: The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells.
    3. Results reveal an unprecedented role for the proline-rich region and the C-terminal domain of metazoan HPat in mRNA decapping and suggest that HPat is a component of the cellular mechanism that couples decapping to deadenylation in vivo.
      Title: HPat provides a link between deadenylation and decapping in metazoa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in P-body assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein associated with topo II related - 1
    Names
    CG5208-PA
    CG5208-PB
    Patr-1-PA
    Patr-1-PB
    lethal (3) 06442

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      17043564..17048421
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300440.1 → NP_001287369.1  protein associated with topo II related - 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287369.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KK29, Q9U6L3, Q9VEN9
      Conserved Domains (1) summary
      pfam09770
      Location:334 → 589
      PAT1; Topoisomerase II-associated protein PAT1

    2. NM_142335.3 → NP_650592.1  protein associated with topo II related - 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650592.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KK29, Q9U6L3, Q9VEN9
      Related
      FBpp0082833
      Conserved Domains (1) summary
      pfam09770
      Location:334 → 589
      PAT1; Topoisomerase II-associated protein PAT1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KK29 Q7KK29
    Q9VEN9 Q9VEN9

    Gene LinkOut

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