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    crm cramped [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31268, updated on 9-Dec-2024

    Summary

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    Official Symbol
    crmprovided by FlyBase
    Official Full Name
    crampedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000376
    Locus tag
    Dmel_CG2714
    See related
    AllianceGenome:FB:FBgn0000376
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2714; Crm; Dmel\CG2714; EG:95B7.2; l(1)3C1; l(1)3Ca; l(1)zw9; sa; sta[P]; swa; zw-9; ZW-9; zw9
    Summary
    Enables chromatin binding activity. Involved in segment specification. Located in nucleus. Is expressed in several structures, including embryonic brain; embryonic/larval salivary gland; gonad; presumptive embryonic/larval nervous system; and primordial germ cell. Orthologous to human CRAMP1 (cramped chromatin regulator homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See crm in Genome Data Viewer
    Location:
    3B3-3B4; 1-1.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2734248..2738773, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2628281..2632806, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43494 Neighboring gene uncharacterized protein Neighboring gene tiny tim 50 Neighboring gene deformed wings Neighboring gene kin of irre Neighboring gene Syntaxin 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic effects associated with band 3C1 of the salivary gland X chromosome of Drosophila melanogaster. Gersh ES. Genetics, 1967 Jun. PMID 6040496, Free PMC Article
    2. The Drosophila Broad-Complex encodes a family of related proteins containing zinc fingers. DiBello PR, et al. Genetics, 1991 Oct. PMID 1743483, Free PMC Article
    3. Molecular analysis of the ecdysterone-inducible 2B5 "early' puff in Drosophila melanogaster. Chao AT, et al. EMBO J, 1986 Jan. PMID 3007111, Free PMC Article
    4. The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen. Yamamoto Y, et al. Development, 1997 Sep. PMID 9310333
    5. Cytogenetic fine structure and chromosomal localization of the white gene in Drosophila melanogaster. Sorsa V, et al. Nat New Biol, 1973 Sep 12. PMID 4125726

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRM is specifically required for the expression of the Histone H1 gene.
      Title: The Polycomb group protein CRAMPED is involved with TRF2 in the activation of the histone H1 gene.
    2. crm modulates the effect of temperature on a genomic region encoding Hedgehog and Wingless signaling effectors.
      Title: Segregating variation in the polycomb group gene cramped alters the effect of temperature on multiple traits.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pattern specification process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in segment specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cramped
    Names
    CG2714-PA
    CG2714-PB
    crm-PA
    crm-PB
    sparse-arista
    stubarista from P32
    swollen-antenna

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2734248..2738773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166951.2 → NP_726829.1  cramped, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726829.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76906, Q0KHW5, Q8MM10, Q8MM41, Q8MM71, Q8MX89, Q8MX90, Q8MX91, Q8MX92, Q8MX93, Q8MX94, Q8MX95, Q9W4V7
      Related
      FBpp0070472
      Conserved Domains (2) summary
      smart00717
      Location:111 → 171
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:113 → 167
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. NM_057757.4 → NP_477105.2  cramped, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477105.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O76906, Q0KHW5, Q8MM10, Q8MM41, Q8MM71, Q8MX89, Q8MX90, Q8MX91, Q8MX92, Q8MX93, Q8MX94, Q8MX95, Q9W4V7
      Related
      FBpp0070473
      Conserved Domains (2) summary
      smart00717
      Location:111 → 171
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:113 → 167
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76906.2 O76906

    Gene LinkOut

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