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    CG2993 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40924, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG2993provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037521
    Locus tag
    Dmel_CG2993
    See related
    AllianceGenome:FB:FBgn0037521
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG2993
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in protein transport. Predicted to be active in cytoplasm. Orthologous to several human genes including ARRDC2 (arrestin domain containing 2); ARRDC3 (arrestin domain containing 3); and ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG2993 in Genome Data Viewer
    Location:
    84E1-84E1; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7804665..7810014, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3630387..3635736, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sugarlethal Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EAST Organizes Drosophila Insulator Proteins in the Interchromosomal Nuclear Compartment and Modulates CP190 Binding to Chromatin. Golovnin A, et al. PLoS One, 2015. PMID 26489095, Free PMC Article
    2. Identification of Drosophila gene products required for phagocytosis of Candida albicans. Stroschein-Stevenson SL, et al. PLoS Biol, 2006 Jan. PMID 16336044, Free PMC Article
    3. Gene expression profiling of brakeless mutant Drosophila embryos. Crona F, et al. Data Brief, 2015 Dec. PMID 26509186, Free PMC Article
    4. Nociceptor-Enriched Genes Required for Normal Thermal Nociception. Honjo K, et al. Cell Rep, 2016 Jul 12. PMID 27346357, Free PMC Article
    5. Tissue-specific (ts)CRISPR as an efficient strategy for in vivo screening in Drosophila. Meltzer H, et al. Nat Commun, 2019 May 8. PMID 31068592, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG2993-PA
    CG2993-PB
    CG2993-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7804665..7810014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275418.1 → NP_001262347.1  uncharacterized protein Dmel_CG2993, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262347.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGR0
      Conserved Domains (2) summary
      pfam02752
      Location:173 → 302
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:5 → 150
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_001275419.1 → NP_001262348.1  uncharacterized protein Dmel_CG2993, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262348.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGD9
      Conserved Domains (2) summary
      pfam02752
      Location:173 → 302
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:5 → 150
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    3. NM_141483.3 → NP_649740.1  uncharacterized protein Dmel_CG2993, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q960Y6, Q9VHZ7
      Related
      FBpp0081268
      Conserved Domains (2) summary
      pfam02752
      Location:173 → 302
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      cl22903
      Location:5 → 150
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGD9 A0A0B4KGD9
    A0A0B4KGR0 A0A0B4KGR0
    Q9VHZ7 Q9VHZ7

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