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    krimp krimper [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36804, updated on 9-Dec-2024

    Summary

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    Official Symbol
    krimpprovided by FlyBase
    Official Full Name
    krimperprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034098
    Locus tag
    Dmel_CG15707
    See related
    AllianceGenome:FB:FBgn0034098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15707; Dmel\CG15707; Krimp; KRIMP; Krimper; mtc
    Summary
    Predicted to enable metal ion binding activity. Involved in negative regulation of gene expression and oogenesis. Located in P granule and perinuclear region of cytoplasm. Is expressed in female germline cell; male germline cell; and organism. Orthologous to human TDRD1 (tudor domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See krimp in Genome Data Viewer
    Location:
    53A1-53A1; 2-79 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16238103..16240722, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12125608..12128227, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclic nucleotide-gated ion channel subunit A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila. Sato K, et al. Fly (Austin), 2015. PMID 26647059, Free PMC Article
    2. Gender-Specific Hierarchy in Nuage Localization of PIWI-Interacting RNA Factors in Drosophila. Nagao A, et al. Front Genet, 2011. PMID 22303351, Free PMC Article
    3. Somatic Primary piRNA Biogenesis Driven by cis-Acting RNA Elements and trans-Acting Yb. Ishizu H, et al. Cell Rep, 2015 Jul 21. PMID 26166564
    4. Targeting and anchoring Tudor in the pole plasm of the Drosophila oocyte. Anne J. PLoS One, 2010 Dec 15. PMID 21179512, Free PMC Article
    5. Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex. Huang X, et al. Nat Commun, 2021 Jul 1. PMID 34210982, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Krimper and Qin proteins play crucial roles in maintaining the levels of piRNAs loaded onto Piwi and Aub to efficiently repress transposons at transcriptional and post-transcriptional levels, respectively.
      Title: Tudor-domain containing proteins act to make the piRNA pathways more robust in Drosophila.
    2. Krimper interacts directly with Aub and Ago3 to coordinate the assembly of the ping-pong piRNA processing complex.
      Title: Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper.
    3. Krimp enforces an antisense bias on piRNA pools by binding AGO3 and blocking its access to primary piRNAs.
      Title: Krimper Enforces an Antisense Bias on piRNA Pools by Binding AGO3 in the Drosophila Germline.
    4. Krimper, a component of the nuage, ensures the repression of selfish genetic elements in the female germ line.
      Title: Unique germ-line organelle, nuage, functions to repress selfish genetic elements in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of oskar mRNA translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte dorsal/ventral axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte karyosome formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in secondary piRNA processing IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in transposable element silencing by piRNA-mediated mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    krimper
    Names
    CG15707-PA
    krimp-PA
    montecristo

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16238103..16240722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137259.4 → NP_611103.2  krimper [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611103.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZAC4
      UniProtKB/TrEMBL
      L0CRJ2
      Related
      FBpp0086333
      Conserved Domains (2) summary
      cd04508
      Location:618 → 662
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      pfam00567
      Location:568 → 679
      TUDOR; Tudor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1ZAC4 A1ZAC4
    Q8IGM1 Q8IGM1
    Q95TQ3 Q95TQ3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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