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    Pal1 Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36033, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pal1provided by FlyBase
    Official Full Name
    Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0283510
    Locus tag
    Dmel_CG12130
    See related
    AllianceGenome:FB:FBgn0283510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0149856.3; CG12130; Dmel\CG12130; dPAL1; DPAL1; PAL1; ta
    Summary
    Enables peptidylamidoglycolate lyase activity. Involved in regulation of imaginal disc-derived wing size. Located in neuronal cell body. Is expressed in several structures, including adult brain; anterior-posterior subdivision of organism; dorsal epidermis primordium; embryonic foregut; and gland. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pal1 in Genome Data Viewer
    Location:
    46C7-46C7; 2-61 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9959549..9963853)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5847054..5851358)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Electron transfer flavoprotein-ubiquinone oxidoreductase Neighboring gene Myocyte enhancer factor 2 Neighboring gene Pdrg1 prefoldin-like subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit j

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Patterned Anchorage to the Apical Extracellular Matrix Defines Tissue Shape in the Developing Appendages of Drosophila. Ray RP, et al. Dev Cell, 2015 Aug 10. PMID 26190146, Free PMC Article
    2. RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development. Song C, et al. Development, 2022 May 1. PMID 35394012, Free PMC Article
    3. Drosophila uses two distinct neuropeptide amidating enzymes, dPAL1 and dPAL2. Han M, et al. J Neurochem, 2004 Jul. PMID 15198673
    4. CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach. Caldeira J, et al. Gut, 2012 Aug. PMID 22052064
    5. Genes for sexual behavior. Yamamoto D, et al. Biochem Biophys Res Commun, 1998 May 8. PMID 9600058

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidylamidoglycolate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in courtship behavior NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in peptide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of imaginal disc-derived wing size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1
    Names
    CG12130-PA
    CG12130-PC
    CG12130-PD
    Pal1-PA
    Pal1-PC
    Pal1-PD
    tapered
    NP_001137630.2
    NP_001286259.1
    NP_610537.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      9959549..9963853
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136693.3 → NP_610537.2  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610537.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960U4, Q9V5E1
      UniProtKB/TrEMBL
      B6IDN2, B7YZR2
      Related
      FBpp0087473
      Conserved Domains (1) summary
      cd14958
      Location:97 → 416
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

    2. NM_001144158.3 → NP_001137630.2  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137630.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q960U4, Q9V5E1
      UniProtKB/TrEMBL
      B6IDN2, B7YZR2
      Conserved Domains (1) summary
      cd14958
      Location:97 → 416
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

    3. NM_001299330.1 → NP_001286259.1  Peptidyl-alpha-hydroxyglycine-alpha-amidating lyase 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286259.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF14
      Conserved Domains (1) summary
      cd14958
      Location:97 → 416
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF14 A0A0B4LF14
    B6IDN2 B6IDN2
    Q9V5E1.1 Q9V5E1

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