Arp3 Actin-related protein 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Arp3provided by FlyBase
Official Full Name: Actin-related protein 3provided by FlyBase
Primary source: FLYBASE:FBgn0262716
Locus tag: Dmel_CG7558
See related: AllianceGenome:FB:FBgn0262716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Actr66B; AcTr66B; anon-WO0172774.138; Arp; arp3; ARP3; arp66b; arp66B; Arp66B; CG7558; Dmel\CG7558; schwachling
Summary: Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to actin filament binding activity. Involved in several processes, including nuclear envelope budding; plasma membrane tubulation; and positive regulation of cellular component biogenesis. Located in cytosol; lamellipodium; and nuclear lamina. Is expressed in adult head and nurse cell ring canal. Human ortholog(s) of this gene implicated in opisthorchiasis. Orthologous to several human genes including ACTR3 (actin related protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 66B6-66B6; 3-22 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8113407..8115902, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8106507..8109002, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material.
Title: Emergence of a smooth interface from growth of a dendritic network against a mechanosensitive contractile material.
Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila.
Title: Activation of Arp2/3 by WASp Is Essential for the Endocytosis of Delta Only during Cytokinesis in Drosophila.
Cofilin promotes phosphate dissociation and severs filaments, generating new pointed ends and rendering Arp2/3-generated networks competent to bind tropomyosin
Title: Arp2/3 complex and cofilin modulate binding of tropomyosin to branched actin networks.
Arp2/3 has an essential role in the process of secretory cargo expulsion and integration of vesicular membranes with the apical plasma membrane.
Title: Arp2/3-mediated F-actin formation controls regulated exocytosis in vivo.
Arp2/3 has a role in PI(4,5)P2 regulation of myoblast fusion in Drosophila
Title: PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site.
data suggest that the Wsp-Arp2/3-based machinery acts in the cyst cells to influence proper microfilament organization and to enable cyst attachment to the base of the testis.
Title: The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release.
The data indicate that WASp-dependent Arp2/3 actin polymerization is crucial for apical presentation of Delta, providing a mechanistic link between actin polymerization and Notch signalling.
Title: The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.
The Arp2/3 complex is required for actin cap expansion and pseudocleavage furrow formation during the syncytial blastoderm divisions.
Title: Arp2/3-dependent pseudocleavage [correction of psuedocleavage] furrow assembly in syncytial Drosophila embryos.
two actin regulators, capping protein, a barbed end binding protein, and the Arp2/3 complex, a potent actin assembly nucleator, function to generate properly organized bundles.
Title: Capping protein and the Arp2/3 complex regulate nonbundle actin filament assembly to indirectly control actin bundle positioning during Drosophila melanogaster bristle development.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
contributes_to actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in Arp2/3 complex-mediated actin nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in Arp2/3 complex-mediated actin nucleation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast fusion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myoblast fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear envelope budding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane tubulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pseudocleavage involved in syncytial blastoderm formation	IPI Inferred from Physical Interaction more info	PubMed
involved_in terminal button organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Arp2/3 protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Arp2/3 protein complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of Arp2/3 protein complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear lamina	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Actin-related protein 3

Names: Actin-related protein; Actin-related protein 66B; Arp3-PA; Arp3-PB; CG7558-PA; CG7558-PB; actin-related protein-3; schwachling

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8113407..8115902 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079244.3 → NP_523968.1 Actin-related protein 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_523968.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9PEY5, P32392, Q9VSD5

Related

FBpp0076460

Conserved Domains (1) summary

PTZ00280
Location:2 → 417

PTZ00280; Actin-related protein 3; Provisional
NM_001274630.1 → NP_001261559.1 Actin-related protein 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261559.1

Status: REVIEWED

UniProtKB/Swiss-Prot

M9PEY5, P32392, Q9VSD5

Conserved Domains (1) summary

PTZ00280
Location:2 → 417

PTZ00280; Actin-related protein 3; Provisional