CycG Cyclin G [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycGprovided by FlyBase
Official Full Name: Cyclin Gprovided by FlyBase
Primary source: FLYBASE:FBgn0039858
Locus tag: Dmel_CG11525
See related: AllianceGenome:FB:FBgn0039858
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-1.25; anon-EST:Liang-2.24; CG 11525; CG11525; chr3R:27424276..27424475; clone 1.25; clone 2.24; cycG; dCycG; Dmel\CG11525; i205; i261
Summary: Enables protein phosphatase inhibitor activity. Involved in several processes, including DNA repair; negative regulation of G1/S transition of mitotic cell cycle; and regulation of signal transduction. Located in polytene chromosome. Is expressed in germarium region 2 and oocyte. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); localized osteosarcoma; ovarian cancer (multiple); and sarcoma. Orthologous to human CCNG1 (cyclin G1) and CCNG2 (cyclin G2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 100C7-100C7; 3-102 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31596642..31612664, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27422364..27438386, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study data suggest that Drosophila melanogaster Cyclin G and the Polycomb complexes PRC1 and PR-DUB cooperate in sustaining developmental stability.
Title: Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.
The metabolic defects of cycG mutant animals are abrogated by a concomitant loss of Wdb, CycG presumably influences Akt1 activity at the PP2A nexus; Well rounded (Wrd), another B' subunit of PP2A in Drosophila, binds CycG similar to Wdb, and that its loss ameliorates some, but not all, of the metabolic defects of cycG mutants.
Title: A triangular connection between Cyclin G, PP2A and Akt1 in the regulation of growth and metabolism in Drosophila.
Loss of CycG modified dominant wing phenotypes of Notch, Delta and Hairless mutants. Whereas Notch loss of function phenotype was ameliorated by a loss of CycG, phenotypes of Notch gain of function or of Delta or Hairless loss of function were enhanced
Title: Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development.
CycG acts at the level of Akt1 to regulate growth and metabolism via PP2A in Drosophila.
Title: Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila.
CycG promotes Gurken-mediated activation of EGFR signalling.
Title: Dorso-ventral axis formation of the Drosophila oocyte requires Cyclin G.
CycG has a role in an early step of meiotic recombination repair.
Title: Cyclin G is involved in meiotic recombination repair in Drosophila melanogaster.
Our results highlight the role of CycG in the control of developmental stability in D. melanogaster
Title: Developmental stability: a major role for cyclin G in drosophila melanogaster.
Cyclin G is encoded by an essential gene, since either RNAi-disruption or cDNA overexpression resulted in high lethality.
Title: More about cyclin G from flies.
Overproduction of Cyclin G produces small cells whereas shortage produces large cells, suggesting that Cyclin G negatively regulates cell growth.
Title: Drosophila melanogaster Cyclin G coordinates cell growth and cell proliferation.
interaction between the Enhancer of Trithorax and Polycomb Corto and Cyclin G is involved in regulating the balance between cell proliferation and cell differentiation during abdominal epithelium development
Title: Regulation of Abd-B expression by Cyclin G and Corto in the abdominal epithelium of Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein phosphatase inhibitor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in female meiotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic DNA repair synthesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin G

Names: CG11525-PA; CG11525-PB; CG11525-PC; CG11525-PD; CG11525-PF; CycG-PA; CycG-PB; CycG-PC; CycG-PD; CycG-PF; cyclin G1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

31596642..31612664 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001276217.2 → NP_001263146.1 cyclin G, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001263146.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95TJ9

Conserved Domains (1) summary

cl00050
Location:287 → 365

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_170557.3 → NP_733436.1 cyclin G, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733436.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95TJ9

Related

FBpp0085160

Conserved Domains (1) summary

cl00050
Location:287 → 365

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_079870.4 → NP_524609.2 cyclin G, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524609.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95TJ9

Related

FBpp0085161

Conserved Domains (1) summary

cl00050
Location:287 → 365

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_170555.3 → NP_733434.1 cyclin G, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733434.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95TJ9

Related

FBpp0085163

Conserved Domains (1) summary

cl00050
Location:287 → 365

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_170556.3 → NP_733435.1 cyclin G, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733435.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95TJ9

Related

FBpp0085164

Conserved Domains (1) summary

cl00050
Location:287 → 365

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...