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    YPS3 aspartyl protease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YPS3
    Official Full Name
    aspartyl protease
    Primary source
    SGD:S000004111
    Locus tag
    YLR121C
    See related
    AllianceGenome:SGD:S000004111; FungiDB:YLR121C; VEuPathDB:YLR121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YPS4
    Summary
    Enables aspartic-type endopeptidase activity. Involved in fungal-type cell wall organization. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human BACE2 (beta-secretase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YPS3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (388744..390270, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ESCRT-I subunit protein SRN2 Neighboring gene aspartyl protease Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Aspartic Protease Yps3p and Cell Wall Glucanase Scw10p Are Novel Determinants That Enhance the Secretion of the Antitumor Triterpenoid GA-HLDOA in Saccharomyces cerevisiae. Fang Y, et al. ACS Synth Biol, 2022 Sep 16. PMID 35969118
    2. HpYPS1 and HpYPS7 encode functional aspartyl proteases localized at the cell surface in the thermotolerant methylotrophic yeast Hansenula polymorpha. Sohn MJ, et al. Yeast, 2012 Jan. PMID 22162039
    3. Identification and characterization of Saccharomyces cerevisiae yapsin 3, a new member of the yapsin family of aspartic proteases encoded by the YPS3 gene. Olsen V, et al. Biochem J, 1999 Apr 15. PMID 10191273, Free PMC Article
    4. Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae. Cho EY, et al. J Biotechnol, 2010 Aug 20. PMID 20599573
    5. Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan. Grbavac A, et al. Biochim Biophys Acta Mol Cell Res, 2017 Mar. PMID 27965112

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fungal-type cell wall organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fungal-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aspartyl protease
    NP_013222.1
    • Aspartic protease; member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      388744..390270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182008.1 → NP_013222.1  TPA: aspartyl protease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013222.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB9, Q12303
      UniProtKB/TrEMBL
      A7A123, C7GQD1, G2WIW3, N1NY91
      Conserved Domains (1) summary
      cd05474
      Location:61 → 396
      SAP_like; SAPs, pepsin-like proteinases secreted from pathogens to degrade host proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12303.1

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