PSR2 putative phosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PSR2
Official Full Name: putative phosphatase
Primary source: SGD:S000004009
Locus tag: YLR019W
See related: AllianceGenome:SGD:S000004009; FungiDB:YLR019W; VEuPathDB:YLR019W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable phosphoprotein phosphatase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of transcription by RNA polymerase II. Located in cytosol. Orthologous to human CTDSP2 (CTD small phosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

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Both PSR1 and PSR2 required for growth under sodium ion stress
Title: Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_013119.1

Putative plasma membrane phosphatase; involved in the general stress response and inactivating dephosphorylation of Mep2p; required along with Psr1p and binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through Msn2p dephosphorylation, and for inhibition of TORC1 in response to limiting amino acids; regulates the sodium ion stress response with Psr1p; member of the HAD family of protein phosphatases

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The following sections contain reference sequences that belong to a specific genome build. Explain