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    HCS1 ATP-dependent 5'-3' DNA helicase HCS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853852, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HCS1
    Official Full Name
    ATP-dependent 5'-3' DNA helicase HCS1
    Primary source
    SGD:S000001500
    Locus tag
    YKL017C
    See related
    AllianceGenome:SGD:S000001500; FungiDB:YKL017C; VEuPathDB:YKL017C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    DIP1
    Summary
    Enables 5'-3' DNA helicase activity. Involved in postreplication repair. Part of DNA helicase A complex and nuclear replisome. Used to study Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Orthologous to human IGHMBP2 (immunoglobulin mu DNA binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HCS1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (405190..407241, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mco12p Neighboring gene WD-repeat containing protein SWD2 Neighboring gene F1F0 ATP synthase subunit d Neighboring gene Put3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA helicase associated with DNA polymerase alpha: isolation by a modified immunoaffinity chromatography. Biswas EE, et al. Biochemistry, 1993 Dec 14. PMID 8257676
    2. Purification and characterization of DNA polymerase alpha-associated replication protein A-dependent yeast DNA helicase A. Biswas SB, et al. Biochemistry, 1997 Oct 28. PMID 9341217
    3. Yeast DNA helicase A: cloning, expression, purification, and enzymatic characterization. Biswas EE, et al. Biochemistry, 1997 Oct 28. PMID 9341218
    4. Random Base Editing for Genome Evolution in Saccharomyces cerevisiae. Pan Y, et al. ACS Synth Biol, 2021 Oct 15. PMID 34542280
    5. Post-replication repair suppresses duplication-mediated genome instability. Putnam CD, et al. PLoS Genet, 2010 May 6. PMID 20463880, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-3' DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in postreplication repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in postreplication repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA helicase A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear replisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent 5'-3' DNA helicase HCS1
    NP_012908.1
    • Hexameric DNA polymerase alpha-associated DNA helicase A; involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      405190..407241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179583.1 → NP_012908.1  TPA: ATP-dependent 5'-3' DNA helicase HCS1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXR9, P34243
      UniProtKB/TrEMBL
      A6ZZU8, B3LR68, B5VMD8, C8ZCF1, G2WI14, N1NZB4
      Conserved Domains (1) summary
      TIGR00376
      Location:15 → 679
      TIGR00376; DNA helicase, putative
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34243.1

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