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    OXP1 5-oxoprolinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853665, updated on 9-Dec-2024

    Summary

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    Official Symbol
    OXP1
    Official Full Name
    5-oxoprolinase
    Primary source
    SGD:S000001698
    Locus tag
    YKL215C
    See related
    AllianceGenome:SGD:S000001698; FungiDB:YKL215C; VEuPathDB:YKL215C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5-oxoprolinase (ATP-hydrolyzing) activity. Involved in glutathione metabolic process. Located in cytoplasm. Orthologous to human OPLAH (5-oxoprolinase, ATP-hydrolysing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See OXP1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (26827..30687, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene monocarboxylate/H+ symporter Neighboring gene dihydroorotate dehydrogenase Neighboring gene Yra2p Neighboring gene Doa1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolomic analysis via reversed-phase ion-pairing liquid chromatography coupled to a stand alone orbitrap mass spectrometer. Lu W, et al. Anal Chem, 2010 Apr 15. PMID 20349993, Free PMC Article
    2. OXP1/YKL215c encodes an ATP-dependent 5-oxoprolinase in Saccharomyces cerevisiae: functional characterization, domain structure and identification of actin-like ATP-binding motifs in eukaryotic 5-oxoprolinases. Kumar A, et al. FEMS Yeast Res, 2010 Jun. PMID 20402795
    3. Random sample consensus combined with partial least squares regression (RANSAC-PLS) for microbial metabolomics data mining and phenotype improvement. Teoh ST, et al. J Biosci Bioeng, 2016 Aug. PMID 26861498
    4. The Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length. Vernekar DV, et al. Nucleic Acids Res, 2021 May 7. PMID 33823531, Free PMC Article
    5. The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner. Samra N, et al. BMC Mol Biol, 2015 Sep 24. PMID 26404137, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-oxoprolinase (ATP-hydrolyzing) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-oxoprolinase
    NP_012707.1
    • 5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      26827..30687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179780.1 → NP_012707.1  TPA: 5-oxoprolinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012707.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWY8, O60212, P28273
      UniProtKB/TrEMBL
      A7A074, B3LQP4, C8ZBW5, G2WHH9, N1P8D6
      Conserved Domains (1) summary
      PLN02666
      Location:4 → 1282
      PLN02666; 5-oxoprolinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28273.2

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