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    SWI3 Swi3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853264, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWI3
    Official Full Name
    Swi3p
    Primary source
    SGD:S000003712
    Locus tag
    YJL176C
    See related
    AllianceGenome:SGD:S000003712; FungiDB:YJL176C; VEuPathDB:YJL176C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HAF2; TYE2
    Summary
    Enables DNA binding activity and histone binding activity. Involved in carbon catabolite activation of transcription from RNA polymerase II promoter; chromatin remodeling; and positive regulation of mating type switching. Located in cytosol and nucleus. Part of SWI/SNF complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 8 and hydrocephalus. Orthologous to human SMARCC1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1) and SMARCC2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWI3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (92053..94530, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Atg27p Neighboring gene ribosomal 60S subunit protein L17B Neighboring gene Kre9p Neighboring gene Rfa3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of SWI1, SWI2, and SWI3 proteins for transcriptional enhancement by steroid receptors. Yoshinaga SK, et al. Science, 1992 Dec 4. PMID 1360703
    2. Isolation of the TYE2 gene reveals its identity to SWI3 encoding a general transcription factor in Saccharomyces cerevisiae. Löhning C, et al. Curr Genet, 1993 Sep. PMID 8221926
    3. N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae. Saeki N, et al. Sci Rep, 2020 Jun 11. PMID 32528012, Free PMC Article
    4. Catalytic activity of the yeast SWI/SNF complex on reconstituted nucleosome arrays. Logie C, et al. EMBO J, 1997 Nov 17. PMID 9362491, Free PMC Article
    5. Structure and function of the SWIRM domain, a conserved protein module found in chromatin regulatory complexes. Da G, et al. Proc Natl Acad Sci U S A, 2006 Feb 14. PMID 16461455, Free PMC Article

    See all (146) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae.
      Title: N-terminal deletion of Swi3 created by the deletion of a dubious ORF YJL175W mitigates protein burden effect in S. cerevisiae.
    2. Structure of the yeast Swi/Snf complex in a nucleosome free state.
      Title: Structure of the yeast Swi/Snf complex in a nucleosome free state.
    3. our data showed that Swi3 strongly affects haem/oxygen-dependent activation of respiration gene promoters whereas Swi2 affects only the basal, haem-independent activities of these promoters. using computational analysis and RNAi knockdown, we showed that the mammalian Swi3 BAF155 and BAF170 regulate respiration in HeLa cells.
      Title: The Swi3 protein plays a unique role in regulating respiration in eukaryotes.
    4. Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement.
      Title: Swi3p controls SWI/SNF assembly and ATP-dependent H2A-H2B displacement.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SWI/SNF complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Swi3p
    NP_012359.1
    • Subunit of the SWI/SNF chromatin remodeling complex; SWI/SNF regulates transcription by remodeling chromosomes; contains SANT domain that is required for SWI/SNF assembly; is essential for displacement of histone H2A-H2B dimers during ATP-dependent remodeling; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; relocates to the cytosol under hypoxic conditions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      92053..94530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181609.1 → NP_012359.1  TPA: Swi3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW13, P32591
      UniProtKB/TrEMBL
      G2WGJ9
      Conserved Domains (1) summary
      COG5259
      Location:253 → 825
      RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32591.1

    Gene LinkOut

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