PSK1 serine/threonine protein kinase PSK1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PSK1
Official Full Name: serine/threonine protein kinase PSK1
Primary source: SGD:S000000015
Locus tag: YAL017W
See related: AllianceGenome:SGD:S000000015; FungiDB:YAL017W; VEuPathDB:YAL017W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FUN31
Summary: Enables protein serine/threonine kinase activity. Involved in negative regulation of glycogen biosynthetic process and regulation of (1->6)-beta-D-glucan biosynthetic process. Located in cytoplasm. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PSK1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_001133.9 (120225..124295)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSK1 coordinates glucose metabolism and utilization and regulates energy-metabolism oscillation in Saccharomyces cerevisiae.
Title: PSK1 coordinates glucose metabolism and utilization and regulates energy-metabolism oscillation in Saccharomyces cerevisiae.
Snf1 phosphorylates and activates Psk1. Once activated, Psk1 may phosphorylate Pbp1, which is known to stimulate stress granule formation and inhibit TORC1 through sequestration. Thus, Psk1 is a link between energy status and cell growth/proliferation.
Title: PAS kinase is activated by direct SNF1-dependent phosphorylation and mediates inhibition of TORC1 through the phosphorylation and activation of Pbp1.
PSK1 mediated in vivo phosphorylation of Cbf1 at T211/T212 inhibits yeast cell respiration.
Title: A comprehensive protein-protein interactome for yeast PAS kinase 1 reveals direct inhibition of respiration through the phosphorylation of Cbf1.
Showed deletion of PSK1 increased sensitivity of yeast to ox. stress&partly inhibited cell growth; but the PSK2-deleted mutant was similar to that of the wild type. SOD1 mRNA and protein levels were lower in PSK1-deletion mutant than the wild type.
Title: PSK1 regulates expression of SOD1 involved in oxidative stress tolerance in yeast.
PAS kinases PSK1 and PSK2 coordinate glucose partitioning in response to metabolic and cell integrity signaling
Title: Yeast PAS kinase coordinates glucose partitioning in response to metabolic and cell integrity signaling.
Yeast PAS kinases phosphorylate UDP-glucose pyrophosphorylase, the primary producer of UDP-glucose and the glucose donor for glucan biosynthesis.
Title: Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of (1->6)-beta-D-glucan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine protein kinase PSK1

NP_009385.2

EC 2.7.11.1

PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

120225..124295

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178162.2 → NP_009385.2 TPA: serine/threonine protein kinase PSK1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009385.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPK1, P31374

UniProtKB/TrEMBL

B5VDK6, N1P9T7

Conserved Domains (1) summary

cd14004
Location:1095 → 1354

STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase