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    SEC11 signal peptidase complex catalytic subunit SEC11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854840, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC11
    Official Full Name
    signal peptidase complex catalytic subunit SEC11
    Primary source
    SGD:S000001461
    Locus tag
    YIR022W
    See related
    AllianceGenome:SGD:S000001461; FungiDB:YIR022W; VEuPathDB:YIR022W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables peptidase activity. Involved in protein targeting to ER and signal peptide processing. Located in endoplasmic reticulum. Part of signal peptidase complex. Orthologous to several human genes including SEC11A (SEC11 homolog A, signal peptidase complex subunit) and SEC11C (SEC11 homolog C, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC11 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (398733..399236)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Mrs1p Neighboring gene uncharacterized protein Neighboring gene Dal81p Neighboring gene Ina22p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SEC11 is required for signal peptide processing and yeast cell growth. Böhni PC, et al. J Cell Biol, 1988 Apr. PMID 3283143, Free PMC Article
    2. Signal peptidase and oligosaccharyltransferase interact in a sequential and dependent manner within the endoplasmic reticulum. Chen X, et al. J Biol Chem, 2001 Jan 26. PMID 11058593
    3. The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase. Estoppey D, et al. Cell Rep, 2017 Apr 18. PMID 28423309
    4. The homologue of mammalian SPC12 is important for efficient signal peptidase activity in Saccharomyces cerevisiae. Fang H, et al. J Biol Chem, 1996 Jul 12. PMID 8663399
    5. The catalytic mechanism of endoplasmic reticulum signal peptidase appears to be distinct from most eubacterial signal peptidases. VanValkenburgh C, et al. J Biol Chem, 1999 Apr 23. PMID 10206957

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein targeting to ER IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal peptide processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptidase complex catalytic subunit SEC11
    NP_012288.1
    • 18kDa catalytic subunit of the Signal Peptidase Complex (SPC); the Signal Peptidase Complex cleaves the signal sequence of proteins targeted to the endoplasmic reticulum; other members are Spc1p, Spc2p, Spc3p, and Sec11p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      398733..399236
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179544.1 → NP_012288.1  TPA: signal peptidase complex catalytic subunit SEC11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012288.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZVU2, B3LTI7, C7GLT4, C8ZAS4, D6VVV3, E7KDY6, E7KQ01, E7LVX4, E7Q587, E7QG89, P15367
      UniProtKB/TrEMBL
      G2WFV0, N1P981
      Conserved Domains (1) summary
      cl10465
      Location:26 → 146
      Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P15367.2

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