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    NSG1 Nsg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856535, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NSG1
    Official Full Name
    Nsg1p
    Primary source
    SGD:S000001175
    Locus tag
    YHR133C
    See related
    AllianceGenome:SGD:S000001175; FungiDB:YHR133C; VEuPathDB:YHR133C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in sterol biosynthetic process. Located in cytosol; endoplasmic reticulum; and nucleus. Orthologous to human INSIG1 (insulin induced gene 1) and INSIG2 (insulin induced gene 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NSG1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (370722..371597, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene putative metallocarboxypeptidase Neighboring gene phosphatase regulator Neighboring gene metalloendopeptidase WSS1 Neighboring gene serine/threonine protein kinase YCK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, et al. EMBO J, 2005 Nov 16. PMID 16270032, Free PMC Article
    2. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. Theesfeld CL, et al. J Biol Chem, 2013 Mar 22. PMID 23306196, Free PMC Article
    3. Quality control of inner nuclear membrane proteins by the Asi complex. Foresti O, et al. Science, 2014 Nov 7. PMID 25236469
    4. Chemogenomic Study of Carboplatin in Saccharomyces cerevisiae: Inhibition of the NEDDylation Process Overcomes Cellular Resistance Mediated by HuR and Cullin Proteins. de Sousa GF, et al. PLoS One, 2015. PMID 26692264, Free PMC Article
    5. Membrane phospholipid alteration causes chronic ER stress through early degradation of homeostatic ER-resident proteins. Shyu P Jr, et al. Sci Rep, 2019 Jun 14. PMID 31201345, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nsg1-mediated stabilization of Hmg2 and the Nsg1-Hmg2 interaction required the early sterol lanosterol.
      Title: Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.
    2. Data show that the yeast INSIG homologs NSG1 and NSG2 function to control the stability of yeast Hmg2p, the HMGR isozyme that undergoes regulated ubiquitination.
      Title: INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables unfolded protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nsg1p
    NP_012001.1
    • Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; forms foci at the nuclear periphery upon DNA replication stress; relocalizes to the cytosol in response to hypoxia; homolog of mammalian INSIG proteins; NSG1 has a paralog, NSG2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      370722..371597 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179263.1 → NP_012001.1  TPA: Nsg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL82, P38837, Q6Q5G1
      UniProtKB/TrEMBL
      A6ZT41, B3LSP7, C7GTW0, C8Z9S8, G2WFK6, N1P9F8
      Conserved Domains (1) summary
      pfam07281
      Location:104 → 290
      INSIG; Insulin-induced protein (INSIG)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38837.1

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