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    PAL2 Pal2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PAL2
    Official Full Name
    Pal2p
    Primary source
    SGD:S000001139
    Locus tag
    YHR097C
    See related
    AllianceGenome:SGD:S000001139; FungiDB:YHR097C; VEuPathDB:YHR097C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SCD1
    Summary
    Located in actin cortical patch and nuclear periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PAL2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    2
    Sequence:
    Chromosome: VIII; NC_001140.6 (297385..298609, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT1 Neighboring gene hexose transporter HXT5 Neighboring gene Sfb3p Neighboring gene histone acetyltransferase TRA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Profiling and verifying the substrates of E3 ubiquitin ligase Rsp5 in yeast cells. Fang S, et al. STAR Protoc, 2023 Sep 15. PMID 37561636, Free PMC Article
    2. Identification of Suppressor of Clathrin Deficiency-1 (SCD1) and Its Connection to Clathrin-Mediated Endocytosis in Saccharomyces cerevisiae. Moorthy BT, et al. G3 (Bethesda), 2019 Mar 7. PMID 30679249, Free PMC Article
    3. The TOR complex 1 is distributed in endosomes and in retrograde vesicles that form from the vacuole membrane and plays an important role in the vacuole import and degradation pathway. Brown CR, et al. J Biol Chem, 2010 Jul 23. PMID 20457600, Free PMC Article
    4. Method for identifying phosphorylated substrates of specific cyclin/cyclin-dependent kinase complexes. Li Y, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049391, Free PMC Article
    5. TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids. Muir A, et al. Elife, 2014 Oct 3. PMID 25279700, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
      Title: Phosphorylation of Pal2 by the protein kinases Kin1 and Kin2 modulates HAC1 mRNA splicing in the unfolded protein response in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pal2p
    NP_011965.1
    • Protein involved in clathrin-mediated endocytosis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YHR097C has a paralog, PAL1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      297385..298609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179227.1 → NP_011965.1  TPA: Pal2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL47, P38809
      UniProtKB/TrEMBL
      A6ZT05, B3LSL2, C7GLY5, G2WFH1, N1P4L9
      Conserved Domains (1) summary
      pfam08316
      Location:131 → 271
      Pal1; Pal1 cell morphology protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38809.1

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