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    MPO1 Mpo1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPO1
    Official Full Name
    Mpo1p
    Primary source
    SGD:S000002978
    Locus tag
    YGL010W
    See related
    AllianceGenome:SGD:S000002978; FungiDB:YGL010W; VEuPathDB:YGL010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables fatty acid alpha-dioxygenase activity. Involved in fatty acid alpha-oxidation and sphingoid catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPO1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (475545..476069)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene delta(24(24(1)))-sterol reductase Neighboring gene proteasome core particle subunit alpha 1 Neighboring gene 3-isopropylmalate dehydratase LEU1 Neighboring gene H(+)-exporting P2-type ATPase PMA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast. Mori K, et al. J Lipid Res, 2020 Jul. PMID 32350077, Free PMC Article
    2. Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids. Kondo N, et al. Nat Commun, 2014 Oct 27. PMID 25345524
    3. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Fisk DG, et al. Yeast, 2006 Sep. PMID 17001629, Free PMC Article
    4. The S. cerevisiae m6A-reader Pho92 promotes timely meiotic recombination by controlling key methylated transcripts. Scutenaire J, et al. Nucleic Acids Res, 2023 Jan 25. PMID 35934316, Free PMC Article
    5. Yeast Mpo1 Is a Novel Dioxygenase That Catalyzes the α-Oxidation of a 2-Hydroxy Fatty Acid in an Fe(2+)-Dependent Manner. Seki N, et al. Mol Cell Biol, 2019 Mar 1. PMID 30530523, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid alpha-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid alpha-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingoid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingoid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mpo1p
    NP_011505.1
    • Dioxygenase that catalyzes alpha-oxygenation of 2-hydroxy fatty acids; involved in metabolism of phytosphingosine; not an essential gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      475545..476069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180875.1 → NP_011505.1  TPA: Mpo1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011505.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUC7, P25338
      UniProtKB/TrEMBL
      A6ZUY3, B3LIM5, B5VIV3, C7GK63, C8Z8N3, G2WE83, N1P206
      Conserved Domains (1) summary
      COG4539
      Location:5 → 174
      COG4539; Uncharacterized membrane protein YGL010W [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25338.2

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