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    KRE2 alpha-1,2-mannosyltransferase KRE2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852094, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KRE2
    Official Full Name
    alpha-1,2-mannosyltransferase KRE2
    Primary source
    SGD:S000002891
    Locus tag
    YDR483W
    See related
    AllianceGenome:SGD:S000002891; FungiDB:YDR483W; VEuPathDB:YDR483W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MNT1
    Summary
    Enables alpha-1,2-mannosyltransferase activity. Involved in N-glycan processing; cell wall mannoprotein biosynthetic process; and protein O-linked glycosylation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See KRE2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1421157..1422485)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase PHO8 Neighboring gene U2-type spliceosomal complex subunit CWC21 Neighboring gene Vps52p Neighboring gene Vps72p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast glycoprotein biosynthesis: MNT1 encodes an alpha-1,2-mannosyltransferase involved in O-glycosylation. Häusler A, et al. Proc Natl Acad Sci U S A, 1992 Aug 1. PMID 1495972, Free PMC Article
    2. Structure of Kre2p/Mnt1p: a yeast alpha1,2-mannosyltransferase involved in mannoprotein biosynthesis. Lobsanov YD, et al. J Biol Chem, 2004 Apr 23. PMID 14752117
    3. Glycosylation in Saccharomyces cerevisiae: cloning and characterization of an alpha-1,2-mannosyltransferase structural gene. Häusler A, et al. Glycobiology, 1992 Feb. PMID 1550992
    4. Localization and targeting of the Saccharomyces cerevisiae Kre2p/Mnt1p alpha 1,2-mannosyltransferase to a medial-Golgi compartment. Lussier M, et al. J Cell Biol, 1995 Nov. PMID 7490293, Free PMC Article
    5. A theoretical study on the catalytic mechanism of the retaining α-1,2-mannosyltransferase Kre2p/Mnt1p: the impact of different metal ions on catalysis. Bobovská A, et al. Org Biomol Chem, 2014 Jun 28. PMID 24831692

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables alpha-1,2-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,2-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall mannoprotein biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,2-mannosyltransferase KRE2
    NP_010771.1
    • Alpha1,2-mannosyltransferase of the Golgi; involved in protein mannosylation; KRE2 has a paralog, KTR6, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1421157..1422485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180791.1 → NP_010771.1  TPA: alpha-1,2-mannosyltransferase KRE2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTA6, P27809
      UniProtKB/TrEMBL
      B3LFI3, B5VH10, C7GKS2, C8Z641, N1P908
      Conserved Domains (1) summary
      COG5020
      Location:35 → 438
      KTR1; Mannosyltransferase [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27809.1

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