RTN1 Rtn1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RTN1
Official Full Name: Rtn1p
Primary source: SGD:S000002641
Locus tag: YDR233C
See related: AllianceGenome:SGD:S000002641; FungiDB:YDR233C; VEuPathDB:YDR233C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in several processes, including ER-dependent peroxisome organization; endoplasmic reticulum organization; and nuclear pore complex assembly. Located in Golgi apparatus; cortical endoplasmic reticulum; and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RTN1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (929470..930357, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

two integral membrane peroxins (proteins required for peroxisome biogenesis) in Saccharomyces cerevisiae, Pex29 and Pex30, reside in distinct regions of the ER and associate with Rtn1 and Yop1, reticulon family members that contribute to ER morphology, to govern peroxisome emergence from the ER.
Title: Peroxins Pex30 and Pex29 Dynamically Associate with Reticulons to Regulate Peroxisome Biogenesis from the Endoplasmic Reticulum.
Rtn1 and Yop1 also physically interacted with Ndc1 and other NPC membrane proteins. We propose that NPC and SPB biogenesis are altered in cells lacking Rtn1 and Yop1 due to competition between these complexes for Ndc1
Title: Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1.
reveal and dissect the critical roles of the reticulon homology domain proteins (Rtn1p, Rtn2p, and Yop1p) in brome mosaic virus RNA replication compartment formation and function
Title: Membrane-shaping host reticulon proteins play crucial roles in viral RNA replication compartment formation and function.
In this study, we report that members of the RTN and Yop1/DP1 families are required for nuclear pore formation.
Title: ER membrane-bending proteins are necessary for de novo nuclear pore formation.
Sbh1p co-precipitates with the ER transmembrane protein Rtn1p. Sbh1p-Rtn1p complexes do not appear to contain Sss1p and Sec61p.
Title: The transmembrane domain is sufficient for Sbh1p function, its association with the Sec61 complex, and interaction with Rtn1p.
The interaction of Rtn1p with the exocyst at the bud tip may trigger the formation of a cortical ER network in yeast buds.
Title: Rtn1p is involved in structuring the cortical endoplasmic reticulum.
The Rtn1 protein is localized predominantly to the endoplasmic reticulum and secondarily to the Golgi.
Title: Saccharomyces cerevisiae Rab-GDI displacement factor ortholog Yip3p forms distinct complexes with the Ypt1 Rab GTPase and the reticulon Rtn1p.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in ER-dependent peroxisome organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network maintenance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in endoplasmic reticulum tubular network organization	IPI Inferred from Physical Interaction more info	PubMed
involved_in nuclear pore complex assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to endoplasmic reticulum stress	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	HDA more info	PubMed
located_in cortical endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: Rtn1p

NP_010519.3

Reticulon protein; involved in nuclear pore assembly and maintenance of tubular ER morphology; promotes membrane curvature; regulates the ER asymmetry-induced inheritance block during ER stress; role in ER-derived peroxisomal biogenesis; increases tubular ER when overexpressed; mutants have reduced phosphatidylserine transfer between the ER and mitochondria; interacts with exocyst subunit Sec6p, Yip3p, and Sbh1p; member of the RTNLA subfamily