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    AFR1 Afr1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AFR1
    Official Full Name
    Afr1p
    Primary source
    SGD:S000002492
    Locus tag
    YDR085C
    See related
    AllianceGenome:SGD:S000002492; FungiDB:YDR085C; VEuPathDB:YDR085C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable actin binding activity. Involved in several processes, including cell morphogenesis involved in conjugation with cellular fusion; mating; and protein localization to bud neck. Located in mating projection base and peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AFR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (614288..616150, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene 25S rRNA (adenine645-N1)-methyltransferase Neighboring gene Tvp23p Neighboring gene translocon subunit SSS1 Neighboring gene Rrp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AFR1 acts in conjunction with the alpha-factor receptor to promote morphogenesis and adaptation. Konopka JB. Mol Cell Biol, 1993 Nov. PMID 8413281, Free PMC Article
    2. Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae. Changwei Z, et al. FEBS Lett, 2007 Jun 12. PMID 17509572
    3. Functional analysis of the interaction between Afr1p and the Cdc12p septin, two proteins involved in pheromone-induced morphogenesis. Giot L, et al. Mol Biol Cell, 1997 Jun. PMID 9201710, Free PMC Article
    4. Afr1p regulates the Saccharomyces cerevisiae alpha-factor receptor by a mechanism that is distinct from receptor phosphorylation and endocytosis. Davis C, et al. Genetics, 1998 Feb. PMID 9504911, Free PMC Article
    5. Transcriptional interference caused by GCN4 overexpression reveals multiple interactions mediating transcriptional activation. Tavernarakis N, et al. Mol Gen Genet, 1995 Jun 10. PMID 7603436

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results indicated that, in addition to its role in establishing pheromone-induced morphogenesis, Afr1p may act as a 'sensor' to transduce cell wall stress resulting from different stimuli to the cell integrity pathway, leading to Slt2p activation.
      Title: Afr1p mediates activation of the Slt2p MAP kinase induced by pheromone, heat shock and hypo-osmotic shock in Saccharomyces cerevisiae.
    2. These results demonstrate a previously unknown role for Afr1 in targeting Glc7 to mating projections and in regulating the septin architecture during mating.
      Title: Saccharomyces cerevisiae Afr1 protein is a protein phosphatase 1/Glc7-targeting subunit that regulates the septin cytoskeleton during mating.
    3. Results indicate that deletion of AFR1 results in mislocalization of Mpk1p.
      Title: Afr1p has a role in regulating the localization of Mpk1p at the shmoo tip in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis involved in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to bud neck IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mating projection base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Afr1p
    NP_010370.1
    • Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; also detected in peroxisomes; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      614288..616150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180393.1 → NP_010370.1  TPA: Afr1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS72, P33304
      UniProtKB/TrEMBL
      B3LGI6, N1P4N5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33304.1

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