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    ARO3 3-deoxy-7-phosphoheptulonate synthase ARO3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851605, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARO3
    Official Full Name
    3-deoxy-7-phosphoheptulonate synthase ARO3
    Primary source
    SGD:S000002442
    Locus tag
    YDR035W
    See related
    AllianceGenome:SGD:S000002442; FungiDB:YDR035W; VEuPathDB:YDR035W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-deoxy-7-phosphoheptulonate synthase activity. Predicted to be involved in aromatic amino acid family biosynthetic process. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARO3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (521816..522928)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene cysteine-rich palmitoylated domain-containing protein CPP3 Neighboring gene mitochondrial 37S ribosomal protein EHD3 Neighboring gene lysine--tRNA ligase KRS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and properties of the 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase (phenylalanine-inhibitable) of Saccharomyces cerevisiae. Paravicini G, et al. Eur J Biochem, 1989 Dec 8. PMID 2574670
    2. Structure of the ARO3 gene of Saccharomyces cerevisiae. Paravicini G, et al. Mol Gen Genet, 1988 Sep. PMID 2906401
    3. Analysis of the structure and transcription of the aro3 cluster gene in Schizosaccharomyces pombe. Nakanishi N, et al. Mol Gen Genet, 1984. PMID 6092844
    4. A nonspecific inhibitory effect of tRNA on the activity of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae. Bell JB, et al. Biochim Biophys Acta, 1976 Jun 2. PMID 6062
    5. Cloning of the ARO3 gene of Saccharomyces cerevisiae and its regulation. Teshiba S, et al. Mol Gen Genet, 1986 Nov. PMID 2880280

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    3-deoxy-7-phosphoheptulonate synthase ARO3
    NP_010320.3
    • 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      521816..522928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180343.3 → NP_010320.3  TPA: 3-deoxy-7-phosphoheptulonate synthase ARO3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010320.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS23, P14843
      UniProtKB/TrEMBL
      A6ZY03, B3LGN0, B5VFT8, C7GQ13, C8Z4V7, G2WAE1
      Conserved Domains (1) summary
      TIGR00034
      Location:15 → 365
      aroFGH; phospho-2-dehydro-3-deoxyheptonate aldolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14843.1

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