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    TRE1 Tre1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRE1
    Official Full Name
    Tre1p
    Primary source
    SGD:S000006097
    Locus tag
    YPL176C
    See related
    AllianceGenome:SGD:S000006097; FungiDB:YPL176C; VEuPathDB:YPL176C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carboxypeptidase activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole. Human ortholog(s) of this gene implicated in breast carcinoma; hemochromatosis (multiple); immunodeficiency 46; multiple myeloma; and ovarian cancer. Orthologous to several human genes including NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRE1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (216012..218363, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene nuclear cap-binding protein subunit CBC2 Neighboring gene Cup9p Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase SPT14 Neighboring gene Nip100p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transferrin receptor-like proteins control the degradation of a yeast metal transporter. Stimpson HE, et al. EMBO J, 2006 Feb 22. PMID 16456538, Free PMC Article
    2. Multiple interactions drive adaptor-mediated recruitment of the ubiquitin ligase rsp5 to membrane proteins in vivo and in vitro. Sullivan JA, et al. Mol Biol Cell, 2007 Jul. PMID 17429078, Free PMC Article
    3. Cell surface polarization during yeast mating. Bagnat M, et al. Proc Natl Acad Sci U S A, 2002 Oct 29. PMID 12374868, Free PMC Article
    4. Diversification at transcription factor binding sites within a species and the implications for environmental adaptation. Ames RM, et al. Mol Biol Evol, 2011 Dec. PMID 21693437
    5. Down-regulation of a manganese transporter in the face of metal toxicity. Jensen LT, et al. Mol Biol Cell, 2009 Jun. PMID 19369420, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tre1p
    NP_015149.1
    • Transferrin receptor-like protein; plasma membrane protein that binds Bsd2p and regulates ubiquitination and vacuolar degradation of the metal transporter Smf1p; functionally redundant with Tre2p; TRE1 has a paralog, TRE2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      216012..218363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183990.1 → NP_015149.1  TPA: Tre1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015149.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3J2, Q08919
      UniProtKB/TrEMBL
      B3LKQ2, B5VSZ5, C7GJC5, C8ZIK2, N1NVP0
      Conserved Domains (3) summary
      cl28883
      Location:221 → 374
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      cd03874
      Location:402 → 617
      M28_PMSA_TfR_like; M28 Zn-peptidase Transferrin Receptor-like family
      pfam04253
      Location:642 → 769
      TFR_dimer; Transferrin receptor-like dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08919.1

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