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    TPO4 Tpo4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854447, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TPO4
    Official Full Name
    Tpo4p
    Primary source
    SGD:S000005799
    Locus tag
    YOR273C
    See related
    AllianceGenome:SGD:S000005799; FungiDB:YOR273C; VEuPathDB:YOR273C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables spermidine transmembrane transporter activity and spermine transmembrane transporter activity. Involved in spermidine transport and spermine transport. Located in fungal-type vacuole membrane and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TPO4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (834452..836431, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ytm1p Neighboring gene tRNA dimethylallyltransferase Neighboring gene Rim20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resistance and adaptation to quinidine in Saccharomyces cerevisiae: role of QDR1 (YIL120w), encoding a plasma membrane transporter of the major facilitator superfamily required for multidrug resistance. Nunes PA, et al. Antimicrob Agents Chemother, 2001 May. PMID 11302822, Free PMC Article
    2. Identification of Saccharomyces cerevisiae genes conferring resistance to quinoline ring-containing antimalarial drugs. Delling U, et al. Antimicrob Agents Chemother, 1998 May. PMID 9593122, Free PMC Article
    3. Multiple polyamine transport systems on the vacuolar membrane in yeast. Tomitori H, et al. Biochem J, 2001 Feb 1. PMID 11171066, Free PMC Article
    4. Identification of the TPO1 gene in yeast, and its human orthologue TETRAN, which cause resistance to NSAIDs. Mima S, et al. FEBS Lett, 2007 Apr 3. PMID 17362938
    5. Localization and function of the yeast multidrug transporter Tpo1p. Albertsen M, et al. J Biol Chem, 2003 Apr 11. PMID 12562762

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables spermidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables spermine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables spermine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermidine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tpo4p
    NP_014916.1
    • Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      834452..836431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183692.1 → NP_014916.1  TPA: Tpo4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X3, Q12256
      UniProtKB/TrEMBL
      G2WNE1, N1NXC2
      Conserved Domains (1) summary
      cd17323
      Location:95 → 546
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12256.1

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