TUM1 thiosulfate sulfurtransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TUM1
Official Full Name: thiosulfate sulfurtransferase
Primary source: SGD:S000005777
Locus tag: YOR251C
See related: AllianceGenome:SGD:S000005777; FungiDB:YOR251C; VEuPathDB:YOR251C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables thiosulfate sulfurtransferase activity. Involved in tRNA wobble position uridine thiolation. Located in mitochondrion. Orthologous to human MPST (mercaptopyruvate sulfurtransferase) and TST (thiosulfate sulfurtransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TUM1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (802550..803464, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of Tum1p in the production of hydrogen sulfide from cysteine
Title: The yeast TUM1 affects production of hydrogen sulfide from cysteine treatment during fermentation.
In this report, we describe the crystal structure of Tum1 protein at 1.90 A resolution which, despite consisting of two RLDs, has only one conserved cysteine residue in the C-terminal RLD.
Title: Crystal structure of the Tum1 protein from the yeast Saccharomyces cerevisiae.
crystals of Tum1p were obtained by the hanging-drop vapour-diffusion method and diffracted to 1.9 A resolution
Title: Crystallization and preliminary X-ray analysis of the yeast tRNA-thiouridine modification protein 1 (Tum1p).

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-mercaptopyruvate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate sulfurtransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables thiosulfate sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables thiosulfate sulfurtransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA wobble position uridine thiolation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA wobble uridine modification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thiosulfate sulfurtransferase

NP_014894.3

EC 2.8.1.1

Rhodanese domain sulfur transferase; accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; involved in metabolism of sterol esters; may be mitochondrially localized

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

802550..803464 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183670.3 → NP_014894.3 TPA: thiosulfate sulfurtransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014894.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2V2, Q08686

UniProtKB/TrEMBL

A6ZP89, C7GWD8, C8ZH03, G2WNB9, N1NVW9

Conserved Domains (1) summary

COG2897
Location:1 → 302

SseA; 3-mercaptopyruvate sulfurtransferase SseA, contains two rhodanese domains [Inorganic ion transport and metabolism]