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    RSB1 phospholipid-translocating ATPase RSB1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854214, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RSB1
    Official Full Name
    phospholipid-translocating ATPase RSB1
    Primary source
    SGD:S000005575
    Locus tag
    YOR049C
    See related
    AllianceGenome:SGD:S000005575; FungiDB:YOR049C; VEuPathDB:YOR049C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables long-chain fatty acid transmembrane transporter activity. Involved in phospholipid translocation and sphingoid long-chain base transport. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RSB1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (422668..423732, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Std1p Neighboring gene ssRNA exonuclease RAT1 Neighboring gene Ett1p Neighboring gene Tmc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of a Saccharomyces cerevisiae gene, RSB1, involved in sphingoid long-chain base release. Kihara A, et al. J Biol Chem, 2002 Aug 16. PMID 12034738
    2. Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria. Panwar SL, et al. J Biol Chem, 2006 Mar 10. PMID 16407254
    3. Loop 5 region is important for the activity of the long-chain base transporter Rsb1. Makuta H, et al. J Biochem, 2017 Feb 1. PMID 28175317
    4. Transcriptional response to deletion of the phosphatidylserine decarboxylase Psd1p in the yeast Saccharomyces cerevisiae. Gsell M, et al. PLoS One, 2013. PMID 24146988, Free PMC Article
    5. Long-chain bases of sphingolipids are transported into cells via the acyl-CoA synthetases. Narita T, et al. Sci Rep, 2016 May 3. PMID 27136724, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that tryptophan transport is increased in pdr5Delta/yor1 strains and reduced in rsb1Delta cells, and the localization and vacuolar degradation of Tat2 were affected in these genetic backgrounds.
      Title: Regulation of yeast nutrient permease endocytosis by ATP-binding cassette transporters and a seven-transmembrane protein, RSB1.
    2. The pH-responsive Rim101 pathway, the protein kinase Mck1, and the transcription factor Mot3 all act in lipid asymmetry signaling and the Rim101 pathway was activated in response to a change in lipid asymmetry.
      Title: The Rim101 pathway is involved in Rsb1 expression induced by altered lipid asymmetry.
    3. Activation of RSB1 transcription is an important feature of the retrograde response allowing normal detoxification of an endogenous sphingolipid precursor.
      Title: Long chain base tolerance in Saccharomyces cerevisiae is induced by retrograde signals from the mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables long-chain fatty acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid translocation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingoid long-chain base transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sphingoid long-chain base transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    is_active_in fungal-type vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid-translocating ATPase RSB1
    NP_014692.1
    • Sphingoid long-chain base (LCB) efflux transporter; integral membrane transporter that localizes to the plasma membrane and may transport long chain bases (LCBs) from the cytoplasmic side toward the extracytoplasmic side of the membrane; role in glycerophospholipid translocation; suppressor of the sphingoid LCB sensitivity of an LCB-lyase mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      422668..423732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183468.1 → NP_014692.1  TPA: phospholipid-translocating ATPase RSB1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014692.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2B5, Q08417
      UniProtKB/TrEMBL
      G2WMT0, N1NY97
      Conserved Domains (1) summary
      pfam04479
      Location:37 → 283
      RTA1; RTA1 like protein
    Nucleotide Protein
    Heading Accession and Version

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