ZWF1 glucose-6-phosphate dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ZWF1
Official Full Name: glucose-6-phosphate dehydrogenase
Primary source: SGD:S000005185
Locus tag: YNL241C
See related: AllianceGenome:SGD:S000005185; FungiDB:YNL241C; VEuPathDB:YNL241C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: MET19; POS10
Summary: Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch and response to hydrogen peroxide. Located in cytoplasm. Used to study congenital nonspherocytic hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ZWF1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (196426..197943, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
Title: Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
Title: An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
Title: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NADP binding	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucose-6-phosphate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables glucose-6-phosphate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADPH regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt	IEA Inferred from Electronic Annotation more info
involved_in pentose-phosphate shunt, oxidative branch	IBA Inferred from Biological aspect of Ancestor more info
involved_in pentose-phosphate shunt, oxidative branch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glucose-6-phosphate dehydrogenase

NP_014158.1

EC 1.1.1.49

Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

196426..197943 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183079.1 → NP_014158.1 TPA: glucose-6-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014158.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0V2, E9P908, P11412

UniProtKB/TrEMBL

A6ZRK2, B3LP80, B5VQG8, G2WLM5, N1NZZ8

Conserved Domains (1) summary

TIGR00871
Location:10 → 489

zwf; glucose-6-phosphate 1-dehydrogenase