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    Y38F1A.2 E3 ubiquitin-protein ligase RNF170 [ Caenorhabditis elegans ]

    Gene ID: 174939, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y38F1A.2
    Official Full Name
    E3 ubiquitin-protein ligase RNF170
    Primary source
    WormBase:WBGene00012606
    Locus tag
    CELE_Y38F1A.2
    See related
    AllianceGenome:WB:WBGene00012606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in autosomal dominant sensory ataxia 1 and hereditary spastic paraplegia 85. Orthologous to human RNF170 (ring finger protein 170). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y38F1A.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (12954958..12958023)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Exocyst complex component Sec10 Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Patched-related protein 18 Neighboring gene ncRNA Neighboring gene G1/S-specific cyclin-D

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactions within the ubiquitin pathway of Caenorhabditis elegans. Gudgen M, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530417
    2. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF170
    NP_496760.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      12954958..12958023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064359.5 → NP_496760.1  E3 ubiquitin-protein ligase RNF170 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWM0
      Conserved Domains (2) summary
      cd16553
      Location:105 → 149
      RING-HC_RNF170; RING finger, HC subclass, found in RING finger protein 170 (RNF170) and similar proteins
      cl01318
      Location:232 → 275
      DUF1232; Protein of unknown function (DUF1232)
    Nucleotide Protein
    Heading Accession and Version

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