Y82E9BR.3 ATP synthase c subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y82E9BR.3
Official Full Name: ATP synthase c subunit
Primary source: WormBase:WBGene00022336
Locus tag: CELE_Y82E9BR.3
See related: AllianceGenome:WB:WBGene00022336
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable lipid binding activity and proton transmembrane transporter activity. Predicted to be involved in proton motive force-driven ATP synthesis. Predicted to be located in mitochondrial membrane. Predicted to be part of proton-transporting ATP synthase complex, coupling factor F(o). Is expressed in body wall musculature; hypodermis; intestine; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in early-onset dystonia and/or spastic paraplegia; renal cell carcinoma; and urinary bladder cancer. Orthologous to several human genes including ATP5MC1 (ATP synthase membrane subunit c locus 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y82E9BR.3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 2

Sequence:: Chromosome: III; NC_003281.10 (1419196..1419773)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the crucial role of Y82E9BR.3 in mitochondrial function and the underlying mechanism of how Y82E9BR.3 regulates lifespan in C. elegans, are reported.
Title: Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proton motive force-driven ATP synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info
part_of proton-transporting two-sector ATPase complex, proton-transporting domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase c subunit

NP_001370803.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

1419196..1419773

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001384026.2 → NP_001370803.1 ATP synthase c subunit [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P90799, Q9BKS0

Conserved Domains (1) summary

MTH00222
Location:42 → 116

ATP9; ATP synthase F0 subunit 9; Provisional